Delta 3,delta 2-Enoyl-CoA isomerase (EC 5.3.3.8), an obligatory auxiliary enzyme for the metabolism of double bonds at odd-numbered positions of fatty acids during their beta-oxidation, was studied in hearts and livers of normal and clofibrate-treated rats. Hepatic peroxisomal and mitochondrial...
Mursula AM, Hiltunen JK, Wierenga RK (2003) Structural studies on delta(3)-delta(2)-enoyl-CoA isomerase: the variable mode of assembly of the trimeric disks of the crotonase super- family. FEBS Lett 557:81-87. doi:10.1016/S0014- 5793(03)01450-9...
Yokota S, Tomioka Y, Suzuki H, Mizugaki M (1993) Immunocytochemical localization of delta 3, delta 2-enoyl-CoA isomerase and NADPH-dependent-2,4-dienoyl-CoA reductase in rat kidney. Histochemistry 99:463–469Yokota, S, Tomioka, Y, Suzuki, H, Mizugaki, M (1993) Immunocytochemical ...
(2000) A novel delta(3),delta(2)-enoyl-CoA isomerase involved in the biosynthesis of the cyclohexanecarboxylic acid-derived moiety of the polyketide ansatrienin A. Biochemistry 39: 7595-7604.Patton et al, " A Novel Δ3, Δ2-Enoyl-CoA Isomerase Involved in the Biosynthesis of the ...
The catalytic domain of the trimeric human (3),(2)-enoyl-CoA isomerase, type 2 (HsECI2), has the typical crotonase fold. In the active site of this fold two main chain NH groups form an oxyanion hole for binding the thioester oxygen of the 3E- or 3Z-enoyl-CoA substrate molecules. A...
The latter compound was isomerized by a novel enzyme, named Delta3,5,7,Delta2,4, 6-trienoyl-CoA isomerase, to 2,4,6-decatrienoyl-CoA, which is a substrate of 2,4-dienoyl-CoA reductase (Wang, H.-Y. and Schulz, H. (1989) Biochem. J. 264, 47-52) and hence can be completely...