This three-ringed molecule has been shown to bind to serum lipoproteins and is believed to exert much of its psychoactive effects by its ability to bind to membranes of cells in the central nervous system (1). The mechanism by which THC exerts psychoactive activity is unknown....
Inositol hexakisphosphate (InsP6) is thought to act as an intercellular signal molecule in the central nervous system. We report that InsP6 stimulates Ca-45(2+) uptake in cultured anterior pituitary cells. This effect is concentration-dependent, is mimicked by inositolpentakis phosphate (InsP5) ...
The docking studies revealed the most probable mode of binding of THC-HS with RAMEB in which the alkyl chain was submerged in the hydrophobic pocket of the CD molecule and hydrogen bonding interactions were observed between the hemisuccinate ester side chain of THC-HS and the rim hydroxy groups...
The reliance of macrophage differentiation upon the M-CSF/CSFR1 axis and iron-dependent intracellular ROS production sets the stage for Δ9-Tetrahydrocannabinol (THC) as a potential target molecule for the interruption of this physiological process. THC, a phytochemical from theCannabisplant, has pote...
Decreased levels of NO2-, a stable degradation product of the short-lived and highly toxic effector molecule NO., were produced by these macrophages. In addition, the effect of the enantiomeric pairs (-)CP55,940/(+)CP56,667 or (-)HU-210/(+)HU-211 on macrophage cell contact-dependent ...
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