On this project we set to characterize the efficacy of Delta-24-RGDOX, an oncolytic adenovirus based on Delta-24-RGD platform, which has demonstrated safety and a therapeutic benefit in different pediatric tumors, armed with the ligand of OX40. The binding of OX40 to OX40L leads to the ...
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但它不能自己进入细胞,而将重组明胶(rGel)与适配体A10偶联后(图4A),就可以通过内化作用进入细胞,并且选择性地作用于PSMA阳性细胞。 图4 溶酶体贮积症(LSD)是一组遗传性代谢疾病,是由于基因突变致溶酶体中有关酸性水解酶缺陷,导致机体中相应的生物大分子不能正常降解而在溶酶体中贮积,引起细胞组织器官功能的障碍...
Briefly, 10 days after the first tumor implantation, we injected OVA-specific CD8+ T cells from OT-I mice into the first tumor, followed by three injections of Delta-24-RGDOX into the same tumor. We found the combination was more potent to inhibit the injected 1st tumor and untreated ...
Delta-24-RGDOXGlioblastoma, the most common primary brain tumor, has a 6.8% survival rate 5 years post diagnosis. Our team developed an oncolytic adenovirus with an OX-40L expression cassette named Delta-24-RGDOX. While studies have revealed the interaction between the gut microbiota and ...
Here, we evaluated changes to gut microbiome in glioma bearing mice treated with viroimmunotherapy. GL261 glioblastoma cells were implanted in the brain of immunocompetent C57BL/6 mice. Then mice were treated with intratumoral injections of control (PBS) or a combination of Delta-24-RGDOX and ...
Thus, we hypothesize that Delta-24-RGDOX potentiates the effect of ACT through activating TME and antigen spread. Methods We used B16-OVA-C57BL/6 subcutaneous (s.c.)/s.c. melanoma model1 to assess systemic therapeutic effect in disseminated tumors. gp100-TCR CD8+ T cells were injected ...
Alpha diversity metrics showed significant differences in richness between the naive and tumor-implanted mice of the PBS (KW p-value=0.049) and Delta-24-RGDOX (KW p-value=0.019) groups, highlighting that tumor presence alters the gut microbiota. Additionally, viroimmunotherapy-treated mice with ...