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P. Biopharmaceutical parameters to consider in order to alter the fate of nanocarriers after oral delivery. Nanomedicine 5, 287–306 (2010). CAS Google Scholar Zhou, X. H. & Po, A. L. W. Peptide and protein drugs: II. Non-parenteral routes of delivery. Int. J. Pharm. 75, 117–...
chemical modifications of drugs, prodrug approach, and conjugation of a drug with immunoglobulins or ligands have been applied in order to enhance the brain targeting. Effective drug delivery system should be designed so as to provide a prolonged residence time in nasal region to overcome the muco...
Traditional Chinese Medicine (MTC) advised the use of acupuncture as a pre-birth treatment starting from the 36th week in order to promote the ripening of the cervix and to relax the mother. In the last 5 years acupuncture some studies applied as pre-birth treatment and in the case of ...
first_page settings Order Article Reprints Open AccessReview Nano-Based Drug Delivery Systems: Potential Developments in the Therapy of Metastatic Osteosarcoma—A Narrative Review by Yuanrui Luo 1,†, Minghao Sun 1,2,†, Linyun Tan 1,2, Tao Li 1,* and Li Min 1,2,* 1 Depar...
However, it is very challenging because of the gastric acidic condition and the difficulty of localizing it in a selected region of the GI tract. In order to overcome these issues, many types of oral controlled drug-delivery systems having extended gastric retention times have been reported such...
In order to formulate such drugs in a safe and efficacious form, a balance must be maintained between bioavailability, toxicity and disposition within the body. Various techniques like micronization, complexation with cyclodextrins, solid dispersions, permeation enhancers and surfactants have been reported...
Colorectal cancer (CRC) is one of the deadliest cancers in the world, the incidences and morality rate are rising and poses an important threat to the public health. It is known that multiple drug resistance (MDR) is one of the major obstacles in CRC tre
[139]. It is worth noting that the implants, loaded with CAR-T cells without CDN, more than doubled the survival rate of mice compared to CAR-T cell therapy alone. However, scaffolds were not able to completely eliminate the tumor, indicating the need to use STING agonists in order to ...