Milk exosomes-mediated miR-31-5p delivery accelerates diabetic wound healing through promoting angiogenesis Chengqi Yan, Jing Chen, Cheng Wang, Meng Yuan, Yu Kang, Zihan Wu, Wenqing Li, Guolei Zhang, Hans-Günther Machens, Yuval Rinkevich, Zhenbing Chen, Xiaofan Yang & Xiang Xu Pages: 214-22...
AD is a progressive neurodegenerative disease with insidious onset. The exact cause and effective treatment are still unclear. Studies have found that MiR-29 is down-regulated in AD, which may be related to the pathogenesis of AD [95]. Jahangard et al.loaded MiR-29 in MSC-EXOs and delivere...
AD is a progressive neurodegenerative disease with insidious onset. The exact cause and effective treatment are still unclear. Studies have found that MiR-29 is down-regulated in AD, which may be related to the pathogenesis of AD [95]. Jahangard et al.loaded MiR-29 in MSC-EXOs and delivere...
Cancer cell membrane decorated silica nanoparticle loaded with miR495 and doxorubicin to overcome drug resistance for effective lung cancer therapy. Nanoscale Res Lett. 2019;14(1):339. https://doi.org/10.1186/S11671-019-3143-3. Nie D, Dai Z, Li J, Yang Y, Xi Z, Wang J, et al. ...
Glioblastoma-associated microglia reprogramming is mediated by functional transfer of extracellular miR-21. Cell Rep. 2019;28(12):3105-3119.e7. Article CAS PubMed PubMed Central Google Scholar Gutmann DH, Kettenmann H. Microglia/brain macrophages as central drivers of brain tumor pathobiology. ...
Their research unveiled a novel intercellular pathway involving USP7, hnRNPA1, exo-miR-522, and ALOX15, which regulates lipid peroxidation levels in tumor cells, impacting their chemotherapy sensitivity.Citation54 On the other hand, tumors or tumor cells can also influence CAFs. Activation pathways ...
The in vivo study resulted in Ggcr8-deficient mice with damage caused by irradiation, showing that miR-200 loaded NPs attenuated the p53 Pathway and promoted intestinal regeneration. The expression of inflammatory factors and the level of ROS in intestinal cells are one of the key factors in ...
miR-124 NPs also induced the migration of neurons into the compromised striatum of the PD model (Fig. 4f, g). An apomorphine-induced rotation behavior test confirmed the role of miR-124 NPs in ameliorating motor symptoms in a PD mouse model (Fig. 4h).132 Briefly, in vitro and in vivo...
To enhance the therapeutic efficacy of MSC-exo, miR-223 was additionally packed into MSC-exo to target the PI3K/Akt signaling pathway, which better reduced apoptosis of AD neurons and promoted neuronal repair in Aβ1–40-induced AD model [167]. In another study, rapamycin, which are an aut...
reduction in miR-21 expression in these cells compared to non-targeted SNALPs, which had no effect on miR-21 expression. Interestingly, miR-21 silencing resulted in increased expression of PTEN and PDCD4, two tumor suppressors modulated by miR-21 [160,161]. Moreover, a reduction in the ...