Polymeric nanocarriers (polymersomes) were loaded with MEK162. The interaction between nanocarrier delivered MEK162, irradiation and TMZ was studied on the kinetics of spheroid growth and on protein expression in the MAPK/ERK pathway. BBB passaging was evaluated in a transwell system with human ...
Preclinical evaluation of binimetinib (MEK162) delivered via polymeric nanocarriers in combination with radiation and temozolomide in gliomadoi:10.1007/S11060-019-03365-YFatima BikhezarRobin De KruijffAstrid J G M van der MeerPeter SminiaKluwer Academic Publishers...