Identification of an Alu element‐mediated deletion in the promoter region of GNE in siblings with GNE myopathyAlu‐SINErepeatarray‐CGHcopy number variantgenomic rearrangementGNEisoformsGNEmyopathyprecision medicinesialic acidGNEmyopathy is a rare genetic disease characterized by progressive muscle atrophy ...
we show that arrayed libraries can be constructed for the genome-wide ablation (19,936 plasmids) of human protein-coding genes and for their activation and epigenetic silencing (22,442 plasmids), with each plasmid encoding an array of four non-overlapping sgRNAs designed to tolerate most human ...
I'm referring to line 1864 where, instead of returning a BitmapIndexed node, its only element is returned.@oberblastmeister Could you clarify the reasoning behind this code?I'm wondering whether this might mess with the shift/subkey-logic, effectively misplacing some elements, so they can't...
A majority of these elements have active chromatin marks, DNase hypersensitivity, and occupancy by multiple transcription factors, which confirms the utility of chromatin signatures in cis-element mapping. Notably, 17 of them are previously annotated promoters of functionally unrelated genes, and like ...
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These data structures are most useful when strategically placed in high-ingestion systems, in parts of the application where they can prevent expensive disk seeks. For example, having an application perform a lookup of an element in a large table on a disk can easily bring down the throughput ...
So... if you are going to increment forward in deletions, you need to use awhileinstead of afor(so that the termination conditions will be re-tested), and when you do a deletion, you need tonotincrement the counter, so that you can examine the element that just "fell down". ...
Given an array of integers, return the maximum sum for a non-empty subarray (contiguous elements) with at most one element deletion. In other words, you want to choose a subarray and optionally delete one element from it so that there is still at least one element left and the sum of ...
hydrophila in zebrafish In the context of fish immunity against bacterial infections, autophagy serves as a crucial element of the inflammatory process, playing a dual role in eliminating damaged organelles and pathogens while also finely regulating the magnitude and duration of the inflammatory response...
We introduce a vertex for every element in U∪F. Let U={a1,a2,…,ar} be the set of vertices corresponding to elements in U, where vertex ai corresponds to element xi∈U and F={b1,b2,…,bt} be the set of vertices corresponding to the elements in F, where vertex bi corresponds ...