Functional analysis concluded that the Cl– extrusion function of L426P and G551D mutants was completely lost, whereas the L311H mutant was still partly functional, and that these functional losses were due to reduced surface expression and glycosylation of these mutants14. However, the study ...
The function of ABA in dormancy is rather well understood, but the role of DOG1 is still unknown. Here, we describe four phosphatases that interact with DOG1 in seeds. Two of them belong to clade A of type 2C protein phosphatases: ABA-HYPERSENSITIVE GERMINATION 1 (AHG1) and AHG3. ...
we still do not fully understand what are the characteristics of these aged HSCs and what causes them to accumulate. By looking at the transcriptomic changes at the single cell scale, we confirmed the global increase of the LTHSC fraction within the HSPCs...
with complex terrain, while it can mitigate partial large-scale turbulence signals. We investigate three parameters that are empirically setup in the correction working flow and inspect their optimal settings, when implementing SSC for quick response after earthquake. Our method is ready to be integrat...
Movie zealots will also find exclusive collections of cinematic stories, comprising of annotated script notes from award-winning actor Gregory Peck, and the full-scale model of the shark from Jaws (c. 1975). Optimistic that the public will experience the museum at its fullest, starting on ...
Still, as this complex acetylates about 38% of all human proteins,15 the downstream targets and molecular mechanisms in vivo remain unclear and other functions of Naa10 could influence the phenotype. Actually, Esmailpour et al.46 could show a loss of TSC2 interaction46 for the truncated Naa...
still limited when compared to other cardiomyopathies due to its rare incidence rate12,13. Mutations in genes such as the troponin T (TNNI2)14, troponin I (TNNI3)15, alpha-cardiac actin (ACTC)16and beta-myosin heavy chain (MYH7)17genes have been shown to be a major cause of ...
2B). Therefore, we confirmed that KCC2 mutant function in our patients was reduced, but still functional, although the collectively reduced function of two mutant alleles is sufficient to cause severe epileptic seizures. The onset of seizures in patients within a few days after birth (Table 1)...