Results Nicotine‐induced inflammatory supernatant promoted the degradation of ECM, such as type II collagen, aggrecan and proteoglycan 4. While in the presence of physiological concentrations of estrogen, this destructive effect is reversed. On the molecular level, estrogen (17β ‐ estradiol, 1?
Receptor-interacting protein 1 (RIP1), an import- ant serine/threonine kinase, possesses a variety of biological functions including cell proliferation, sur- vival and death. The physiological roles of RIP1 in OA have not been reported before. Here, we found that AGEs increased the expression ...
Extra Cellular Matrix (ECM) Degradation is one of the properties of metastatic cancer cells. A membrane structure called invadopodia is thought to be responsible to this property in cancer cells. It has been found in some invasive cancer cell but not yet in hepatocellular carcinoma (HCC). PAK4...
aIn conclusion, it is believed the venture of the GCISS is a feasible entity. Due to the increasingly large number of Chinese students within the Gold Coast region, the need for support services with a focus on the Chinese market is paramount. There is little competition in this area and ...
Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes. Kraut A, Coute Y, Block M, Albiges-Rizo C, Destaing O: Roles of paxillin family members in adhesion and ECM degradation coupling at invadosomes. J... Christos,Petropoulos,Christiane,... - 《Journal ...
Zbang Y, Wei L, Yu J,et al.Targeting of the beta6 gene to suppress degradation of ECM via inactivation of the MAPK pathway in breast adenocarcinoma cells [J] .Oncol Rep,2014, 32(5) : 1787-1795.Zhang Y, Wei L, Yu J, Li G, Zhang X, Wang A, et al. Targeting of the beta6 ...
Degradation of fluorescent ECM networks by SPARC.Alexandre, ChlenskiLisa, J. GuerreroHelen, R. SalwenQiwei, YangYufeng, TianAndres, Morales La MadridSalida, MirzoevaPatrice, G. BouyerDavid, XuMatthew, Walker
M. 2015. Regulation of ECM degradation and axon guidance by growth cone invadosomes. Development, 142, 486-96.M. Santiago-Medina, K.A. Gregus, R.H. Nichol, S.M. O'Toole, T.M. Gomez, Regulation of ECM degradation and axon guidance by growth cone invadosomes, Dev. Camb. Engl. ...
Cells secrete enzymes, such as matrix metalloproteinases (MMPs), in order to degrade some of the proteins in the ECM and migrate through it. Our 3D model of cell migration serves to investigate how the degradation rate of the ECM influences quantities important for cell-ECM interactions and ...
Simulations were performed for global and highly localized matrix degradation processes, where the latter occurred at the cell–ECM interface. It was observed that the higher the speed of the cell boundary, the higher the matrix concentration after localized degradation. The results showed that a ...