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In the first class, two FOs, EML4-ALK and CCDC6-RET, incorporate enzymatic domains from receptor tyrosine kinases and promote oncogenic Ras signaling by undergoing liquid–liquid phase separation (LLPS) to form cytoplasmic condensates that exhibit elevated kinase activity16,17,18. These FOs display...
Genes used to annotate cell identity are indicated by the corresponding colors. A complete list of marker genes is provided in Table S5. (C) Violin plots showing expression of key marker genes. p values are from two-sided Wilcoxon rank-sum tests. (D) Gene scoring analysis using the ...