Analysis of plants expressing functional GFP-tagged versions of GL1, GL3 and TRY show that the proteins are localized in trichome nuclei. These results have been used to model trichome initiation in terms of protein interactions and threshold levels of activator complex. 展开 ...
study individuals who carry an autosomal dominantly inherited AD (ADAD) mutation in the amyloid precursor protein (APP), presenilin 1 (PSEN1) or presenilin 2 (PSEN2) gene that leads to increased relative production of the Aβ42 peptide throughout life and early brain Aβ plaque deposition11,12...
including expression of some basal epithelial cell markers44,45. Gene expression profiling fromBRCA1heterozygous breast tissue showed similarities between luminal progenitor cells and basal-like breast tumors, and between luminal mature cells and luminal A/B tumors44....
These cells have a large in-frame deletion that removes 67% of the coding sequence of the Wiz gene (including zinc fingers 2–5), likely resulting in a null allele. Western blot analysis confirmed that an epitope within the deleted region is not detected in Wizdel cells. Wizdel cells may...
2. “the essential error consists in the drawing of categorical conclusions from dimensional analyses.” and, “inconsistencies in characterizing the phenotype should be noted. mehta et al repeatedly equivocated on the terms posttraumatic stress disorder, ptsdsymptoms, and probableptsd. in fact, the ...
such as perturbed nuclear organization as a result of the altered juxtacentromeric or telomeric heterochromatin organization[18–20], deregulated expression of small regulatory microRNAs (miRNA)[21] or changes in replication timing[22] may also have a deep impact on the deregulation of gene expression...
Moreover, specific RET haplotypes have been found to have either protective or predisposing effects, or to modulate the severity of the resulting phenotype.6–12 In particular, specific haplotypes comprising the rarer allele of a single nucleotide polymorphism (SNP) of exon 2 (A45A) have been ...
Developmental programs of multicellular organisms require the establishment of defined temporal and spatial patterns of gene expression. In higher plants, the initiation of flowering is the first step in reproductive development, and is controlled by a complex regulatory network that converges on the tran...
P53 pathway defects (TP53 mutation, CDKN2A deletion) and MYC gene family amplification were the only disease features, which were significantly associated at relapse (Figure S2A). In patients receiving standard upfront radiotherapy and chemotherapy, these defects emerged in combination and were significa...
Intestinal stromal cells are known to modulate the propagation and differentiation of intestinal stem cells1,2. However, the precise cellular and molecular mechanisms by which this diverse stromal cell population maintains tissue homeostasis and repair are poorly understood. Here we describe a subset of...