This 'stage-based' terminology can be used to supplement terms with ambiguous meanings (e.g. invasive, introduced, naturalized, weedy, etc.), and thereby improve clarity of future studies. This approach is based
Therefore, we performed further targeted analysis of the predefined DEGs (Tables S3 and S5) using DESeq2 with a design including interaction terms as outlined in the methods. Focusing on the responders at PRE, 18 shared DEGs were detected between both treatments, with 78 DEGs (adjusted p < ...
New NGS methods have far superior resolution and are more adept at describing diversity. They are also often considerably cheaper in terms of both labor and reagent costs. Metagenomics Metagenomics is defined as culture independent, direct genetic analysis of genomes within environmental samples (Thomas...
6g). We observed translation Gene Ontology terms enriched in cluster 4 and splicing and RNA-processing Gene Ontology terms enriched in cluster 2 (Extended Data Fig. 6k). Clusters of genes that gradually reduce expression along the transition from normal colon to cancer (clusters 6–9) and ...
In terms of ion annotation, we converted the raw mass spectrometry data into a readable format (mzXML) using Proteowizard's MSConvert software. Subsequently, we conducted peak extraction and quality control using XCMS, and the substances extracted were subjected to ion annotation using CAMERA. Our ...
The GO terms distribution showed that the Secrebiome was mainly composed of Hydrolase activity (18.4%) at Molecular Function (Additional file 8: Fig. S5a), membrane (37%) at Cellular Component (Additional file 8: Fig. S5b); and organic substance metabolic process (21%) at Biological ...
Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in situ localization across three cohorts of patients with IBD (total n
BMC Genomics (2021) 22:589 https://doi.org/10.1186/s12864-021-07902-w RESEARCH Open Access Increased abundance of secreted hydrolytic enzymes and secondary metabolite gene clusters define the genomes of latent plant pathogens in the Botryosphaeriaceae Jan H. Nagel*, Michael J. Wingfield and ...
George Obiero2, Philip Bejon1,3, Jean Langhorne4, Abdirahman Abdi1 and Lynette Isabella Ochola‑Oyier1* Abstract Background Cumulative malaria parasite exposure in endemic regions often results in the acquisition of partial immunity and asymptomatic infections...
For example, dogs have been found to be approximately 2.5 times less sensitive to QT prolongation in terms of the magnitude of response22. Due to the measurement of both the PK and PD response simultaneously, a PKPD relationship was developed to predict the FPD changes obtained in these models...