a, Summary of benign breast duct cell types and BC subtypes. The image was created with BioRender.com.b, Sample grid processing method utilized in the study to perform various assays on each tumor sample systematically.c, Summary of data types available for single-cell, single-nucleus and ST ...
It has been reported that melatonin can protect stem cells by scavenging radicals, upregulating antioxidant enzyme expression, reducing the activity of pro-oxidant enzymes, and maintaining mitochondrial homeostasis77. More encouragingly, data from animal and human studies have proven that short-term use ...
Fibroblasts present in areas of tissue injury generally have been regarded to arise by recruitment from surrounding connective tissue; however this may not be the only source of these cells.Materials and MethodsLong-term culture of adherent, human, and murine leukocyte subpopulations was combined with...
Cancer progression and survival rates following anatomical radical retropubic prostatectomy in 3,478 consecutive patients: long-term results. J Urol. 2004;172:910–4. Article PubMed Google Scholar Freedland SJ, Humphreys EB, Mangold LA, Eisenberger M, Dorey FJ, Walsh PC, et al. Risk of ...
Moreover, costs of prolonged chemotherapy regimens in terms of long-term sequelae in children treated for ALL are considerable 2, 3, 4, 5, 6. If the efficacy of current treatments is reaching a plateau, then additional therapeutic interventions are needed, ideally with fewer toxicities than ...
Long-term culture of alveolospheres This paper GEO (GSE137799) Experimental Models: Cell Lines Human: Normal donor iPSC line targeted with NKX2-1GFP SFTPCtdTomato (BU3 NGST) Kotton Lab (Jacob et al., 2017) http://www.bu.edu/dbin/stemcells/ Human: Donor iPSC line targeted with SFTPCt...
The genes needed to monitor a given pathway we term “pathway reporter genes”. Here, we use a panel of 917 reporter genes compiled based on information from public and proprietary databases covering about 150 human metabolic and signaling networks. We show that molecular phenotyping allows fast ...
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we combine genomic sequencing and high-content imaging approaches on iPSCs from 297 unique donors to investigate the relationship between genetic variants and cellular morphology to map what we term cell morphological quantitative trait loci (cmQTLs). We identify novel associations between rare protein ...
The only long-term survivors were infants receiving RT at recurrence (four of four, median overall survival 17 years (range 8.9–19.2 years); Figures S1F–S1H; Table 1). Combined MYC and P53 Defects Commonly Emerge at Medulloblastoma Relapse P53 pathway defects (TP53 mutation, CDKN2A deletion)...