We also observe a cluster of cancer-associated fibroblasts (CAFs) consisting almost exclusively of cells from CRCs, and a scATAC cluster of fibroblasts enriched for cells from polyps and CRCs with accessibility around some of the same genes as CAFs, which we term pre-cancer-associated fibroblasts...
Male reproductive system ageing is closely associated with deficiency in testosterone production due to loss of functional Leydig cells, which are differentiated from stem Leydig cells (SLCs). However, the relationship between SLC differentiation and age
We also observe a cluster of cancer-associated fibroblasts (CAFs) consisting almost exclusively of cells from CRCs, and a scATAC cluster of fibroblasts enriched for cells from polyps and CRCs with accessibility around some of the same genes as CAFs, which we term pre-cancer-associated fibroblasts...
Make the Definition Evaluative The idea of a "problem" usually means that people think there is something wrong with the world, but wrong is a debatable term. Even if everyone accepts the same facts, not everyone will agree that the facts you (or others) have defined as a prob- lem ...
To reduce redundancy in protein identification, peptides identified from tandem spectra were reassigned to proteins using the following procedure: (1) all peptides identified by MS/MS spectra were searched against protein databases to define whether each peptide was unique or shared (i.e., whether...
the candidate genes: (i) mutation intolerance (pLI score > 0.84 and RVIS% < 32); (ii) FMRP and RBFOX target enrichment; and (iii) variants in genes where genome-wide de novo significance had not been established in the recent meta-analysis9. The procedure prioritized 58 ASD ...