5a)23. This cluster of fibroblasts exhibited the highest expression of RSPO3, a factor that supports the intestinal stem cell niche24. We also observe a cluster of cancer-associated fibroblasts (CAFs) consisting almost exclusively of cells from CRCs, and a scATAC cluster of fibroblasts enriched ...
Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in situ localization across three cohorts of patients with IBD (total n
A central aim of developmental biology is to better understand the embryonic differentiation and maturation pathways that lead to functioning adult cells and tissues. Multistage, stepwise differentiation protocols applied to cultured human PSCs are designed to recapitulate these pathways in order to produce...
Microbial consortia composed of autotrophic and heterotrophic species abound in nature, yet examples of synthetic communities with mixed metabolism are limited in the laboratory. We previously engineered a model cyanobacterium, Synechococcus elongatus PC
2 Kaplan Meier overall survival curves for chromosome 1q status (a, b), TNC (c, d) and WHO grade (e, f) in the recent (1992–2014; a, c, e) and the entire cohort (1965–2014; b, d, f) long-term follow-up, as well as the possibility to rescue patients with recurrence, ...
5a)23. This cluster of fibroblasts exhibited the highest expression of RSPO3, a factor that supports the intestinal stem cell niche24. We also observe a cluster of cancer-associated fibroblasts (CAFs) consisting almost exclusively of cells from CRCs, and a scATAC cluster of fibroblasts enriched ...
We observed heterotrophic growth dependent upon cyanobacterial photosynthate in each co-culture pair. Furthermore, these synthetic consortia could be stabilized over the long-term (weeks to months) and both species could persist when challenged with specific perturbations. Stability and productivity of aut...
Cancers converge onto shared patterns that arise from constraints placed by the biology of the originating cell lineage and microenvironment on programs driven by oncogenic events. Here we define consistent expression modules reflecting this structure in
Sato, T. et al. Single Lgr5 stem cells build crypt-villus structuresin vitrowithout a mesenchymal niche.Nature459, 262–265 (2009). CASPubMedGoogle Scholar Ciriello, G. et al. Emerging landscape of oncogenic signatures across human cancers.Nat. Genet.45, 1127–1133 (2013). ...
Osteopontin-cd44 signaling in the glioma perivascular niche enhances cancer stem cell phenotypes and promotes aggressive tumor growth. Cell Stem Cell 2014, 14, 357–369. [CrossRef] [PubMed] 64. Niemczyk, M.; Ito, Y.; Huddleston, J.; Git, A.; Abu-Amero, S.; Caldas, C.; Moore, G....