In our biophysical model, for simplicity and because of insufficient information in the literature about the different factors examined, we did not incorporate any information about the factors’ recycling dynamics (binding/unbinding at the plasma membrane, diffusion at the membrane and the cytoplasm,...
2. The use of multiple neurotransmitters enhances a neuron’s capacity to encode information within a circuit, allowing for more complex patterns of synaptic interactions to emerge, and the opportunity to differentially influence the activity of synaptic partners over multiple timescales3. Many neurons...