Male reproductive system ageing is closely associated with deficiency in testosterone production due to loss of functional Leydig cells, which are differentiated from stem Leydig cells (SLCs). However, the relationship between SLC differentiation and age
Drug resistance is a principal limitation to the long-term efficacy of cancer therapies. Cancer genome sequencing can retrospectively delineate the genetic basis of drug resistance, but this requires large numbers of post-treatment samples to nominate causal variants. Here we prospectively identify geneti...
Ageing Res Rev 10: 370–378. [21] Newman AB, Arnold AM, Sachs MC, Ives DG, Cushman M, et al. (2009) Long-term function in an older cohort–the cardiovascular health study all stars study. J Am Geriatr Soc 57: 432–440. [22] NCHS (2010) Health United States 2009 with Special ...
The ageing of world population has a direct impact on the health and care systems, as it means an increase in the number of people needing care which leads to higher care costs and the need for more resources. In this context, informal caregivers play an important role as they enable ...
Drug resistance is a principal limitation to the long-term efficacy of cancer therapies. Cancer genome sequencing can retrospectively delineate the genetic basis of drug resistance, but this requires large numbers of post-treatment samples to nominate ca
There may be significant limitations for current flourishing frameworks where existing flourishing definitions are based on wellbeing (note, the term positive mental health is often used synonymously), as the results from our community survey suggest a number of mental health indicators, in addition ...
we combine genomic sequencing and high-content imaging approaches on iPSCs from 297 unique donors to investigate the relationship between genetic variants and cellular morphology to map what we term cell morphological quantitative trait loci (cmQTLs). We identify novel associations between rare protein ...
Further on, the efficiency of oxidative phosphorylation (OXPHOS) was evaluated in term of P/O value, calculated as the ratio between ATP synthesis (ATP-synth) and oxygen consumption rate (OCR). These parameters were evaluated in the presence of pyruvate + malate (Pyr + Mal) or succ...
population that can differentiate into both plasma cells and GC B cells after reexposure to antigen10,11. If this were the case, it is possible that all MBCs retain self-renewal potential as well as terminal differentiation potential, with the fate of the cell being determined by environmental...
In addition to surgery, they’re used in hospitals and labs for repetitive tasks, in rehabilitation, physical therapy and in support of those with long-term conditions. We are living much longer than previous generations, and as we approach the end of life, we are dying in a dif...