Drug resistance is a principal limitation to the long-term efficacy of cancer therapies. Cancer genome sequencing can retrospectively delineate the genetic basis of drug resistance, but this requires large numbers of post-treatment samples to nominate causal variants. Here we prospectively identify geneti...
Male reproductive system ageing is closely associated with deficiency in testosterone production due to loss of functional Leydig cells, which are differentiated from stem Leydig cells (SLCs). However, the relationship between SLC differentiation and age
Drug resistance is a principal limitation to the long-term efficacy of cancer therapies. Cancer genome sequencing can retrospectively delineate the genetic basis of drug resistance, but this requires large numbers of post-treatment samples to nominate ca
There may be significant limitations for current flourishing frameworks where existing flourishing definitions are based on wellbeing (note, the term positive mental health is often used synonymously), as the results from our community survey suggest a number of mental health indicators, in addition ...
The ageing of world population has a direct impact on the health and care systems, as it means an increase in the number of people needing care which leads to higher care costs and the need for more resources. In this context, informal caregivers play an important role as they enable ...
This message is reinforced by the popularization of high-protein fad diets, which promise speedy weight loss. Some short-term studies have found that high protein intake improves glucose control in humans (Dong et al., 2013; Gannon et al., 2003; Seino et al., 1983). However, long-term ...
First and foremost is thevalue challengethat all countries across the globe are facing – there is escalating demand from long-term, chronic disease, rising costs, often with an ageing population and limited resources. Yet we are continuing to invest in facilities and equipment that were built...
simple laboratory robots to highly complex surgical robots that can either aid a human surgeon or execute operations by themselves. In addition to surgery, they’re used in hospitals and labs for repetitive tasks, in rehabilitation, physical therapy and in support of those with long-term ...
The biochemical analyses were performed on mononuclear cells isolated from peripheral blood, obtained from a healthy population with an age between 5 and 106 years. In particular, we have evaluated the oxidative phosphorylation function and efficiency, the ATP/AMP ratio, the lactate dehydrogenase ...
we combine genomic sequencing and high-content imaging approaches on iPSCs from 297 unique donors to investigate the relationship between genetic variants and cellular morphology to map what we term cell morphological quantitative trait loci (cmQTLs). We identify novel associations between rare protein ...