Drug resistance is a principal limitation to the long-term efficacy of cancer therapies. Cancer genome sequencing can retrospectively delineate the genetic basis of drug resistance, but this requires large numbers of post-treatment samples to nominate causal variants. Here we prospectively identify geneti...
More encouragingly, data from animal and human studies have proven that short-term use of melatonin elicits only mild adverse effects, such as dizziness, headache, nausea, and sleepiness, even in extreme doses78. Here, we explored melatonin’s effect in restoring Nestin expression and MERCs, ...
Long-term results of Taiwan Pediatric Oncology Group studies 1997 and 2002 for childhood acute lymphoblastic leukemia High-risk B-lineage ALL, T-cell, CD10 negativity, t(9;22), infant, and higher leukocyte count were consistently adverse factors, whereas hyperdiploidy... DC Liang,CP Yang,DT ...
[64]). It seems obvious that there is a solution to the question of whether a single analogue is within the domain of another molecule, without making prior assumptions of what is acceptable in term of differences. It is highly likely that mechanistic similarity is a pre-requisite for ...
Antihypertensive effects of vitamin C, particularly by reducing systolic blood pressure, have been shown in short-term trials [40]. Based on this evidence, it was concluded that vitamin C may be a useful nutritional intervention for the secondary prevention of CVD [2]. Furthermore, vitamin C ...
We next investigated whetherKeap1/Nrf2mutations in HN-CSCs had any adverse impact on progression-free survival (PFS) and overall survival (OS). Patients whose tumors harboredKeap1/Nrf2mutations in HN-CSCs had significantly shorter PFS (log-rankp< 0.001) and OS (log-rankp= 0.007) than the ...