Alzheimer’s disease (AD) pathology develops many years before the onset of cognitive symptoms. Two pathological processes—aggregation of the amyloid-β (Aβ) peptide into plaques and the microtubule protein tau into neurofibrillary tangles (NFTs)—are
In some cases, these emergent interactions limit heterotrophic growth and/or stability. By mitigating bottlenecks to heterotrophic growth, we demonstrate that each of our co-cultures can persist over the long-term (days to months): an important feature that is often missing in synthetic cross-...
Postsynaptic density (PSD) proteins have been implicated in the pathophysiology of neurodevelopmental and psychiatric disorders. Here, we present detailed clinical and genetic data for 20 patients with likely gene-disrupting mutations inTANC2—whose protein product interacts with multiple PSD proteins. Pedi...
We observed heterotrophic growth dependent upon cyanobacterial photosynthate in each co-culture pair. Furthermore, these synthetic consortia could be stabilized over the long-term (weeks to months) and both species could persist when challenged with specific perturbations. Stability and productivity of aut...
the viral sncRNAs upon TSA treatment in U2OS cells (Fig.1f, S1) whereas these sncRNAs were not detected in solvent control (DMSO) treated samples except for sncRNA-U86, which was detected in low amount even in solvent control treated samples. Thus our results showed a unique stage in ...
Finally, the growth model provides us with a third method to get at the elastic properties of the cell wall, albeit now looking at the long-term elasticity of a growing cell wall. We therefore explored what values of the Young’s modulus to turgor pressure ratio and Poisson’s ratio ...
Antihypertensive effects of vitamin C, particularly by reducing systolic blood pressure, have been shown in short-term trials [40]. Based on this evidence, it was concluded that vitamin C may be a useful nutritional intervention for the secondary prevention of CVD [2]. Furthermore, vitamin C ...