Onceitwaspossibletodefinemaleandfemaleroleseasilybythedivisionoflabor.Menworkedoutsidethehomeandearnedtheincometosupporttheirfamilies,whilewomencookedthemealsandtookcareofthehomeandthechildren.Theseroleswerefirmlyfixedformostpeople,andtherewasnotmuchopportunityforwomentoexchangetheirroles.Butbythemiddleofthiscentury,...
Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that characterize the subtype-specific tumor-normal lineages are not established. In this work, we applied bulk, single-cell and single-nucleus multi-omic techniques as well as ...
Hormone-sensitive lipase appears as the major lipase for catecholamine and natriuretic peptide-stimulated lipolysis whereas adipose triglyceride lipase mediates the hydrolysis of triglycerides during basal lipolysis. Translocation of hormone-sensitive lipase bound to the adipocyte lipid binding protein to the ...
Hormone-sensitive lipase appears as the major lipase for catecholamine and natriuretic peptide-stimulated lipolysis whereas adipose triglyceride lipase mediates the hydrolysis of triglycerides during basal lipolysis. Translocation of hormone-sensitive lipase bound to the adipocyte lipid binding protein to the ...
Applied to the regulated secretion of neuropeptides, this adjustable reserve function would have interesting implications for our understanding of the dynamic propensity of neurons to modulate the release of their neuropeptides. In Lymnaea, release of the ovulation hormone requires priming by a prolonged...
New approaches to the understanding of tamoxifen action and resistance. Tamoxifen (TAM) provides an effective agent for treatment of hormone-dependent breast cancer but resistance uniformly ensues upon continued use. Additional... LM Berstein,HW Zheng,JP Wang,... - Endocrine-related cancer 被引量:...
excluded if they reported a history of chronic disease (diabetes, heart or liver disease, high blood pressure, gastrointestinal disorder), recent weight loss or gain (> 3 kg over the past 8 weeks), had abnormal blood or urine values, or use of oral contraceptives or hormone replacement ...
For example, one naturally occurring mutation in the thyroid-stimulating hormone (TSH) receptor has been identified to couple to a Gαs-dependent signaling pathway, resulting in a complete loss of the Gαq-dependent signaling cascade [49]. It has also been demonstrated that naturally occurring ...
Phosphatidylinositol 4,5-bisphosphate (PIP2) is required for successful completion of cytokinesis. In addition, both PIP2 and phosphoinositide-specific phospholipase C (PLC) have been localized to the cleavage furrow of dividing mammalian cells. PLC hydr
the stress hormone system, or hypothalamus-pituitary-adrenal (hpa) axis, is likely an important mediator of such gene 脳 environment interactions because it is activated by traumatic events and dysregulated in a number of psychiatric disorders, including ptsd. in fact, hpa axis dysfunction with ...