Fig. 1: Single-cell atlas of expression and chromatin accessibility in CRC development. a, Summary of the samples in this study. The bar chart shows the number of normal/unaffected colon tissues (gray), adenomas (purple) and CRCs (red) assayed for each patient. Locations of samples assayed...
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Clinical outcome for patients suffering from HPV-negative head and neck squamous cell carcinoma (HNSCC) remains poor. This is mostly due to highly invasive tumors that cause loco-regional relapses after initial therapeutic intervention and metastatic out
The activities of SVP and FLC were studied by ChIP PCR on individual target genes, and their genome-wide binding maps were characterized separately by ChIP followed by sequencing (ChIP-seq) or ChIP-on-chip approaches [3,4,9]. This analysis led to the identification of pathways in which each...
Acta Neuropathologica Communications (2016) 4:88 DOI 10.1186/s40478-016-0349-9 RESEARCH Open Access Chromosome 1q gain and tenascin-C expression are candidate markers to define different risk groups in pediatric posterior fossa ependymoma Asuka Araki1,6,7,8, Monika Chocholous2,6, Johannes Gojo...
Patients were excluded from either tumor cell collection or vaccination if they had significant organ dysfunction, active infection, or a history of autoimmune disease. Off-study criteria after the start of vaccination included progressive leukemia indicated by a white cell count >200,000 cells/mm3....
International Journal of Radiation Oncology, Biology, PhysicsSuzuki M,Nishimura Y,Nakamatsu K,et al.Analysis of interfractional set-up errors and intrafractional organ motions during IMRT for head and neck tumors to define an appropriate planning target volume(PT)-and planning or- gans at risk ...
The gut is an essential metabolic, endocrine, and immune organ inhabited by millions of microbes. Recently, our knowledge of the diversity of microorganisms in the human gut has exponentially increased with the development of high-throughput sequencing technologies [1]. The intestinal microorganism comm...
Fig. 1: Single-cell atlas of expression and chromatin accessibility in CRC development. a, Summary of the samples in this study. The bar chart shows the number of normal/unaffected colon tissues (gray), adenomas (purple) and CRCs (red) assayed for each patient. Locations of samples assayed...
period of metastasis development, tumor cells are actively adapting to the stresses of a different organ’s cellular millieu in order to ultimately grow in an uncontrolled manner. This transitional middle phase may provide a unique clinical opportunity, yet the underlying biology remains largely ...