Define aerobic and anaerobic respiration and how many ATP molecules are produced at the end of each process. Define substrate-level phosphorylation and oxidative level phosphorylation, in which stage during cellular respiration does each of them produce A ...
Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex. Cell Rep. 2014;7(1):19-26.Horejsi Z, Stach L, Flower TG, Joshi D, Flynn H, Skehel JM, O'Reilly NJ, Ogrodowicz RW, Smerdon SJ, Boulton SJ. Phosphorylation-dependent PIH1D1 ...
Rab10 is a well-known substrate of LRRK2, and in vitro assays suggested that PD-related neurodegeneration may start byLRRK2-G2019S increasing phosphorylation of Rab10102. It is also known that Rab10 is involved in LRRK2 and other Rabs relocalization103. Therefore, it is not surprising tha...
H. et al. Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. Nucleic Acids Res. 49, 2266–2288 (2021). Article CAS PubMed PubMed Central Google Scholar Geraghty, R. J. et al. Guidelines for the use of cell lines in ...
In the context of targeted therapies and the imperative patient stratification, this implies that future phase II clinical trials should be performed according to the prior detection of STAT3 Y705 phosphorylation on biopsies. STAT3 inhibitors, or drugs that are targeting this...
Antigen/antibody complexes were visualized using the SuperSignal West Pico Plus and/or the SuperSignal West Femto Maximum Sensitivity Substrate from Thermo Fisher Scientific (Rockford, IL; Cat. # 34580 and 34095, respectively). Statistical methods The primary objective was to evaluate the association ...
In addition, due to the general enzymatic substrate specificity of flavonol-glycosyltransferases, which have a higher selectivity toward sugar donors but often share flavonol aglycones as sugar acceptors, K3Glc2″Api6″Rha and K3Glc2″Api6″Rha7Glc were found to have the expected retention time...
H. et al. Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition. Nucleic Acids Res. 49, 2266–2288 (2021). Article CAS PubMed PubMed Central Google Scholar Geraghty, R. J. et al. Guidelines for the use of cell lines in ...
Rab10 is a well-known substrate of LRRK2, and in vitro assays suggested that PD-related neurodegeneration may start byLRRK2-G2019S increasing phosphorylation of Rab10102. It is also known that Rab10 is involved in LRRK2 and other Rabs relocalization103. Therefore, it is not surprising tha...
J. Endosomal localization and receptor dynamics determine tyrosine phosphorylation of hepatocyte growth factor-regulated tyrosine kinase substrate. Mol. Cell. Biol. 20, 7685–7692 (2000). Article PubMed PubMed Central CAS Google Scholar Harris, T. W., Hartwieg, E., Horvitz, H. R. & ...