Define the term radiation buffer used in chemistry. Define the terms clearly and concisely. Give two examples of substance. What does the term substrate mean? What does the term \lambda_{max} mean? Define copolymer and give an example. What do cis and trans mean? Define scientific law and...
Although the functions of MTTases in bacteria and eukaryotes have been established via detailed genetic and biochemical studies, MTTases from the archaeal domain of life are understudied and the substrate specificity determinants of MTTases remain unclear. Here, we report the ...
The liquid crystal polymer network is that a liquid crystal polymer having a higher glass transition temperature than an operation temperature of the liquid crystal is perpendicularly arranged to the planes of the substrate by a voltage of 1 to 100 V and hardened as it is. Preferably, the ...
The model also predicted that His-171 in hGH may be involved in substrate binding. The H171N hGH mutant was found to have a 250-fold reduced V max . These studies to determine the catalytic mechanism begin to define the three dimensional interactions of hGH with poly-γ-glutamate substrates...
The role played by cell-substrate interactions in the pathogenesis of osteoclast-mediated peri-implant osteolysis Prosthetic wear debris-induced peri-implant osteolysis is a major cause of aseptic loosening after total joint replacement. In this condition, wear particl... Z Shen,TN Crotti,KP Mchugh...
Rab10 is a well-known substrate of LRRK2, and in vitro assays suggested that PD-related neurodegeneration may start byLRRK2-G2019S increasing phosphorylation of Rab10102. It is also known that Rab10 is involved in LRRK2 and other Rabs relocalization103. Therefore, it is not surprising tha...
ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage. Science 2007; 316:1160- 6; PMID:17525332; http://dx.doi.org/10.1126/sci- ence.1140321 40. Yan SJ, Lim SJ, Shi S, Dutta P, Li WX. Unphosphorylated STAT and heterochromati...
Rab10 is a well-known substrate of LRRK2, and in vitro assays suggested that PD-related neurodegeneration may start byLRRK2-G2019S increasing phosphorylation of Rab10102. It is also known that Rab10 is involved in LRRK2 and other Rabs relocalization103. Therefore, it is not surprising tha...
The model also predicts that His-171 is involved in substrate binding but not catalysis. Site-directed mutagenesis of these conserved amino acids followed by characterization of the purified mutant proteins was used to test the predictions of the model. Determination of the active site fold is the...
While our model cannot be considered an atomic structure of the T2SS pseudopilus, it provides a valuable path to testable predictions, such as the importance of XcpH helix unraveling, possible substrate binding sites available on the filament tip, the presence of dynamic contacts between XcpG and...