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In mathematics, computer science and physics, a deterministic system is a system in which no randomness is involved in the development of future states of
Where this has not been done, even if partners on the opposing membrane exist, a role in tethering has to be taken as untested. Class 3: sorter/recruitment proteins Sorting and recruitment proteins work to define the contact-site proteome and lipidome. This can be done by active recruitment...
b-d, Sorting and gating strategy to isolate and expand TIL cultures prior to co-culture. b. TILs grown in IL2 or OKT3-stimulated for 72 hours and analyzed after 4 hours of PMA-I-stimulation. FMO, fluorescent-minus-one control b. TILs from 2686 retain ability to induce IFNγ and ...
the role of Rab17 in PD progression is not fully understood. At the phosphoprotein level, only Rab12 (p < 0.005) was significantly upregulated in LRRK2 PD (Supplementary Fig.12a). Rab12 is an LRRK2 endogenous substrate that plays a role in endosomal lysosome sorting, degradation, and...
The endosomal sorting complex required for transport (ESCRT) machinery mediates cargo sorting, membrane deformation and membrane scission on the surface of endosomes, generating intraluminal vesicles (ILVs) to degrade signaling receptors. By live-cell imaging of individual endosomes in human cells, we ...
the role of Rab17 in PD progression is not fully understood. At the phosphoprotein level, only Rab12 (p < 0.005) was significantly upregulated in LRRK2 PD (Supplementary Fig.12a). Rab12 is an LRRK2 endogenous substrate that plays a role in endosomal lysosome sorting, degradation, and...
The preadipocyte population was initially purified by depletion of the stromal vascular fraction from macrophages (CD14- and CD206-positive cells) and endothelial cells (CD31-positive cells) using fluorescence-activated cell sorting. At confluence, cells were harvested and used for Assay for Transposase...