2b). As expected, we detected three main classes of drug resistance variants, with drug-sensitizing variants now largely absent for the combination therapy (8 with the combination therapy versus 111 with trametinib). Collectively, these data demonstrate that base editing screens can reveal ...
Antibiotic treatment failure in Pseudomonas aeruginosa chronic lung infections is associated with increased morbidity and mortality, illustrating the clinical challenge of bacterial infection control. Understanding the underlying infection environment, as well as the host and bacterial factors driving antibiotic ...
Of 37 patients with resected breast tumors, samples were obtained from 26 patients before treatment and 11 patients following therapy (Supplementary Table1). Systemic treatment regimens for previously treated patients included carboplatin and paclitaxel; doxorubicin and cyclophosphamide followed by paclitaxel;...
Client taking the feelings (pleasant and unpleasant) they have about someone and while discussing it in therapy put those feelings towards/on the therapist as if the therapist was that personAll emotions once expressed about an individual, now expressed towards therapistJosef Breuer discovered this wi...
Synovial mesenchymal stem cells (MSCs) have high freeze–thaw tolerance, whereas human umbilical vein endothelial cells (HUVECs) have low freezing tolerance. The differences in cell type-specific freeze–thaw tolerance and the mechanisms involved are unc
The study identified 120 patients (number of biopsies per assay detailed in Figure S1A) treated with anti-PD-1 monotherapy (nivolumab or pembrolizumab; n = 63 patients) or combined anti-CTLA-4 and anti-PD-1 therapy (nivolumab or pembrolizumab combined with ipilimumab; n = 57 patients). Pati...
Having a cup of coffee with your “ideal client” is a great and effective process to stay focused and uncover deep truths. It is much like a Gestalt therapy approach to conflict resolution and taking care of “unfinished business” with another. Put the person/problem/pain/solution in the ...
As Atomic CSS (also known as Functional CSS) has been gaining in popularity, some confusion has occurred about similar related terms. The goal of this article
Discoidin domain receptor 2 signaling networks and therapy in lung cancer. J Thorac Oncol. 2014;9:900–4. Article CAS PubMed PubMed Central Google Scholar Jing H, Song J, Zheng J. Discoidin domain receptor 1: new star in cancer-targeted therapy and its complex role in breast carcinoma....
While other studies focused on end point comparisons, we are the first to show distinct changes at the level of chromatin occur multiple times throughout lung colonization. Furthermore, these temporally resolved changes point in the direction of a host of metastasis dependency genes that lie ...