To emulate virus infection, the interaction of EPRS1 and SARS-CoV-2 RNA was interrogated in a SARS-CoV-2 replicon generated in a hybrid bacterial/yeast reverse genetics system (Fig.6a). TheN-ORF is disrupted with EGFP, generating ΔN-EGFP sgRNAs that renders transfected 293 T cells amena...