The column oven was maintained at 35 °C, and the flow rate was 0.4 mL/min. The mobile phase consisted of solvent A (water, 0.1% formic acid) and solvent B (acetonitrile, 0.1% formic acid). A high‐resolution tandem mass spectrometer (TripleTOF5600plus, SCIEX) was used to detect the...
In a titration process, a solution where the concentration is known is called the "titrant". The titrant is slowly added to the solution with the unknown concentration, called the "analyte". Titrants are usually done with acids and bases, and can ...
Is the transformation product formed; is rate and extent of formation similar (Toxicokinetics) UVCB / Mixtures: Focus on similarity of chemical profile with regard to structures / proportion of structures and link to activity (Chemistry and Toxicodynamics) Analogue / Category Approach:All aspects ...
Like all chemical processes the reagents (energy sources of food) react during life to produce vital energy, but in addition also create the next generation of life. This latter reaction is unique in that a simple proportional increase in the reagents creates an exponential increase in products:...
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been recognized as genetic risk factors for Parkinson’s disease (PD). However, compared to cancer, fewer genetic mutations contribute to the cause of PD, propelling the search for protein b
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been recognized as genetic risk factors for Parkinson’s disease (PD). However, compared to cancer, fewer genetic mutations contribute to the cause of PD, propelling the search for protein b
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, generates multiple protein-coding, subgenomic RNAs (sgRNAs) from a longer genomic RNA, all bearing identical termini with poorly understood roles in regulating
Afterin vitroenzymatic digestion of thrombin, the reaction was stopped by acidifying the samples. The peptides were then dried and reconstituted in 0.1% formic acid (FA). Peptides were separated and analysed on a Dionex Ultimate 3000 RSLC nanoLC system coupled to a Q-Exactive tandem mass spect...
Emission probability for a cell along a path is a function of the location of the state and a gene specific parameter for each gene in the cell which controls the rate of change of its expression along the path. Split nodes are locations where paths split and are associated with a branch...
bated. After a subsequent wash, the tetramethylbenzidine substrate solution is added for color development. The reaction is stopped with sulfuric acid solution, and OD is measured at 450 nm using a plate reader. Index is calculated by dividing the OD value for the samples by the OD of the ...