Is the transformation product formed; is rate and extent of formation similar (Toxicokinetics) UVCB / Mixtures: Focus on similarity of chemical profile with regard to structures / proportion of structures and link to activity (Chemistry and Toxicodynamics) Analogue / Category Approach:All aspects ...
EVs (primarily exosomes and microvesicles) are lipid bilayer-coated nanoparticles secreted by all cell types. The secretion of EVs was initially considered a means of eliminating proteins, lipids, and RNA from inside the cells18. With accumulating evidence, EVs have become recognized as a very impo...
functional, and therapeutic perspective. However, wound fluid proteolytic products, including TCPs, may also serve as a “window” into the wound microenvironment. We therefore hypothesized that the peptide profile could reflect the action of different proteases present in wounds. However, ...
(2.6 μm, 150Å, ThermoFisher Scientific, San Jose, CA). For each analysis, we loaded ≈2 μg onto the column and separation was achieved using a 2.5h h gradient of 7 to 27% acetonitrile in 0.125% formic acid at aflow rateof ≈550 nL min−1. Each analysis used an SPS-MS3-...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, generates multiple protein-coding, subgenomic RNAs (sgRNAs) from a longer genomic RNA, all bearing identical termini with poorly understood roles in regulating
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been recognized as genetic risk factors for Parkinson’s disease (PD). However, compared to cancer, fewer genetic mutations contribute to the cause of PD, propelling the search for protein b