Significance is determined by comparing each cell type with a background of all other cell types. d, Hypergeometric enrichment of TF motifs in stromal cell marker peaks. e, Plot of maximum difference between chromVAR deviation z-score, depicting TF motif activity, against correlation of chromVAR ...
We discuss possible cell–cell interactions between stromal and epithelial cells along the malignant continuum in a Supplementary Note and in Extended Data Fig. 8f,g. Comparing CRC DNA methylation changes with continuum accessibility Aberrant DNA methylation is a primary mechanism of tumorigenesis in ...
Similarly to cyclodextrins, this scaffold has received interest owing to its ability to accommodate guests such as sugars and hereby form inclusion complexes [92,93]. Also found naturally [94], the versatility in the degree of rigidity in the cyclophane scaffold has enabled the proposal of laborat...
This resonates with other participants who spoke of cultural rootedness in connection with family and its importance to their sense of identity. It is often in the absence of this rootedness that its significance is most felt. Some spoke of the impact it had, as a sense of spirit loss to ...