The mechanism underlying selective myelination of axons versus dendrites or neuronal somata relies on the expression of somatodendritic membrane myelination inhibitors (i.e. JAM2). However, axons still present long unmyelinated segments proposed to contribute to axonal plasticity and higher order brain func...
Therefore, the first and foremost principle is that cell types are the product of evolution and cell type identities are encoded in the genome. Like phylogenomics for species classification, transcriptomic (and epigenomic) classification is a good proxy of cell type classification as the gene regulato...
and the balance of gene number associated with individual modules. Strikingly, when using EPG parsimonious matrices, the network method (FastUnfold) provided the most significant enrichment and segregation of ontology terms. This was a particular feature of the combination of FastUnfold with parsimonious...