Molecular studies define the primary structure of alpha 1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of ACT in hip- pocampus and liver. J Biol Chem 1999;274:1821-1827.Hwang SR, Steineckert B, Kohn A, Palkovits M, Hook VY (1999) Mo- lecular ...
Orsay virus infection of enterocytes leads to the induction of LGG-1 (a homolog of the mammalian LC3 protein) puncta, raising the possibility that ubiquitin-mediated autophagy could be a conserved antiviral pathway in the intestine. An overview of antiviral pathways present in enterocytes in C. ...
editing can provide insights into protein structure–function relationships, including critical domains and residues, which could be valuable in drug discovery campaigns. Four classes of variants modulating drug sensitivity The integration of 46 mutagenesis screens led to the identification of four ...
In the current study we investigate TUBA4A, a structural microtubule protein with mutations causal to familial ALS, using molecular-dynamic (MD) modeling of protein structure to predict the effects of each mutation and its overall impact on GTP binding, chain stability, tubulin assembly, and ...
Protein–protein interaction networks using these essential gene lists also highlighted proteins in the purine pathway being major ‘hub’ proteins which have a large number of interactors across the network. When adding in two more species (C. lari and C. hyointestinalis) the essential gene list...
These data highlight that base editing can provide insights into protein structure–function relationships, including critical domains and residues, which could be valuable in drug discovery campaigns. Four classes of variants modulating drug sensitivity The integration of 46 mutagenesis screens led to ...
Describe the structure and function of a generalized human somatic cell. Define peroxisomes Define hypotonic Describe neurons, cell bodies, dendrites, and axons. Define turgid in biology Describe cellular organelles bounded by two lipid-protein membranes. Define differentially permeable membrane. What is ...
From these contigs, we obtained 115,712 open reading frames (ORF) containing a protein sequence. Notably, > 54% of the total reads from the eight samples mapped back to the assembly, suggesting that our assembly covers a broad fraction of the sequence spectrum for all the samples (Fig...
How do the structures of the nitrogenous bases affect their function? A buffer is: A)a substance that stabilizes pH B)a protein that catalyzes a faster chemical reaction C)a string of multiple peptides D)a molecule that hydrolyzes sugar molecules a) Define the term anomeric carbon. b) In ...
A protein is a large, complex macromolecule composed of one or more long chains of amino acids. Proteins are 15-25% nitrogen and an equal amount of oxygen, and are present in and vital to every living cell. They are essential for the structure, function, and regulation of the body's ti...