Molecular studies define the primary structure of alpha 1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of ACT in hip- pocampus and liver. J Biol Chem 1999;274:1821-1827.Hwang SR, Steineckert B, Kohn A, Palkovits M, Hook VY. Molecular studies define ...
In the current study we investigate TUBA4A, a structural microtubule protein with mutations causal to familial ALS, using molecular-dynamic (MD) modeling of protein structure to predict the effects of each mutation and its overall impact on GTP binding, chain stability, tubulin assembly, and ...
Orsay virus infection of enterocytes leads to the induction of LGG-1 (a homolog of the mammalian LC3 protein) puncta, raising the possibility that ubiquitin-mediated autophagy could be a conserved antiviral pathway in the intestine. An overview of antiviral pathways present in enterocytes in C. ...
These data highlight that base editing can provide insights into protein structure–function relationships, including critical domains and residues, which could be valuable in drug discovery campaigns. Four classes of variants modulating drug sensitivity The integration of 46 mutagenesis screens led to ...
Protein–protein interaction networks using these essential gene lists also highlighted proteins in the purine pathway being major ‘hub’ proteins which have a large number of interactors across the network. When adding in two more species (C. lari and C. hyointestinalis) the essential gene list...
These data highlight that base editing can provide insights into protein structure–function relationships, including critical domains and residues, which could be valuable in drug discovery campaigns. Four classes of variants modulating drug sensitivity The integration of 46 mutagenesis screens led to ...
Describe the structure and function of a generalized human somatic cell. Define peroxisomes Define hypotonic Describe neurons, cell bodies, dendrites, and axons. Define turgid in biology Describe cellular organelles bounded by two lipid-protein membranes. Define differentially permeable membrane. What is ...
What are the four main classes of macromolecules important to life? What are the monomers of proteins? Which macromolecules are different forms of cellular information required to run the cell? A) RNA, protein and lipids B) Nucleic acids, fatty acids and sugars C) DNA, RNA and proteins D)...
After total protein concentration was assessed using BCA Protein Assay Kit (Thermo), equal amount of protein was resolved by SDS polyacrylamide gel electrophoresis and then electrotransferred to a 0.45 μm pore-sized polyvinylidene difluoride membrane (Millipore, Darmstadt, Germany). The target ...
(FACS)-sorted luminal epithelial cells from reduction mammoplasties showed gene expression similarity between ductal KRT15+luminal progenitors and published signatures of basal-like BC47. These studies have largely focused on protein markers and gene expression patterns. In this study, we apply single-...