Molecular studies define the primary structure of alpha1-antichymotrypsin (ACT) protease inhibitor in Alzheimer's disease brains. Comparison of act in hipp... An alpha1-antichymotrypsin-like serpin has been implicated in Alzheimer's disease (AD) based on immunochemical detection of alpha1-...
(ii) Each protein in the biological system has a unique three-dimensional structure and has specific biological activity This is called native form of a ptotein When a protein in its native form is subjected to physical changes such as change in temperature pH etc hydrogen bonds are broken Due...
Nodes form the structure of XMLports and the structure of the XML document or text file that is to be imported from or exported to. Each node has several important properties that can be accessed directly from Visual Studio Code. The following sections describe each node and its properties....
In the current study we investigate TUBA4A, a structural microtubule protein with mutations causal to familial ALS, using molecular-dynamic (MD) modeling of protein structure to predict the effects of each mutation and its overall impact on GTP binding, chain stability, tubulin assembly, and ...
Prostate adenocarcinoma (PRAD) persists as the predominant non-cutaneous malignancy diagnosed in males, which is a primary contributor to cancer-related mortality globally. It is reported that the progression of prostate adenocarcinoma is associated with
Molecular cloning has revealed the primary structure of a number of G-protein-linked receptors. The organization and topography of these proteins predicted to have seven hydrophobic membrane-spanning domains, in contrast, have not been established. Antibodies were prepared against 11 peptides ...
A knowledge gap in understanding of the T2SS is the molecular role of a small “pseudopilin” protein. Using multiple biophysical techniques, we have deciphered how this missing component of the Xcp T2SS architecture is structurally integrated, and thereby unlocked its function. We demonstrate ...
Why is the protein hemoglobin necessary for successful circulation of oxygen? Portion of hemoglobin molecule that binds O2 - Fe2+ - ferritin - globin - heme - transferrin Explain the flow of a hemoglob...
After total protein concentration was assessed using BCA Protein Assay Kit (Thermo), equal amount of protein was resolved by SDS polyacrylamide gel electrophoresis and then electrotransferred to a 0.45 μm pore-sized polyvinylidene difluoride membrane (Millipore, Darmstadt, Germany). The target ...
T cell exhaustion, which occurs in response to chronic antigen stimulation and is characterized by reduced cytokine production and increased expression of inhibitory receptors, is thought to be a primary mechanism of immune evasion by cancers19,20. To further support the observation of T cell ...