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Global smaller amplitude changes across much of XcpHp suggest that the XcpHp:Jp interaction subtly affects the dynamics or the structure of the entire XcpHp molecule. Download: Download high-res image (562KB) Download: Download full-size image Figure 3. XcpHp chemical-shift perturbations due to...
In addition, domains within the 123 amino acids at the C-terminal end of the molecule directly bind protein kinases (Rosenstein et al, 1999). Immunohistochemical analysis using the antibody SSGZ demon- strates that 95% of breast tumours exhibit nuclear expression of the C-terminal domain of ...
However the conservative substitution to serine, that maintained polarity with a small decrease in size of the side chain, did not change AZ10606120 sensitivity. These results suggest that polar amino acids at positions 90 and 94 are important for high affinity AZ10606120 binding....