ClinicalBiasNeuroscienceNeuronal plasticitySynaptogenesisBrainAlthough neuroscientific findings have significantly increased knowledge in the clinical field, the field literature has highlighted some limitations that the use of these findings involves. In......
Cell state changes in the brain are closely related to neural plasticity. Similarly, various diseased conditions can induce pathological changes in cell states in different brain regions or tissue organs. Numerous studies have revealed selective vulnerability of specific cell types for specific diseases....
The mechanism underlying selective myelination of axons versus dendrites or neuronal somata relies on the expression of somatodendritic membrane myelination inhibitors (i.e. JAM2). However, axons still present long unmyelinated segments proposed to contribute to axonal plasticity and higher order brain func...
This study is among the first to define the cellular and molecular mechanisms underlying the differential release of cotransmitter substances from individual presynaptic terminals, which allow for context-dependent tuning and plasticity of the synaptic networks underlying patterned motor behaviour....
Epithelial cell plasticity drives endoderm formation during gastrulation Nat. Cell Biol., 23 (2021), pp. 692-703, 10.1038/s41556-021-00694-x Google Scholar 34 M. Lolas, P.D.T. Valenzuela, R. Tjian, Z. Liu Charting Brachyury-mediated developmental pathways during early mouse embryogenesis Pr...
Moreover, GSC resists conventional radiotherapy and chemother- apy through their relative quiescence and plasticity [7]. Therefore, targeting GSC through identified cell surface markers has become a significant focus and this approach has showed promise to eliminate neoplastic progression in preclinical ...
If both autism and epilepsy can be considered as disorders of synaptic plasticity [143, 144], autism and epilepsy may be the consequences of the same pathophysiological mechanisms, resulting in abnormal plasticity of genetic origin. Numerous genetic conditions that associate autism and epilepsy in ...
If both autism and epilepsy can be considered as disorders of synaptic plasticity [143, 144], autism and epilepsy may be the consequences of the same pathophysiological mechanisms, resulting in abnormal plasticity of genetic origin. Numerous genetic conditions that associate autism and epilepsy in ...
DEVELOPMENTAL PLASTICITY Plasticity is a universal quality of living things as they develop. Within the limits imposed by its genes and by mechanical constraints, each individual has a range of options for its life history and final body form and function...
lungprogenitors directed differentiation cell fate cellular plasticity heterogeneity single cell RNA sequencing DNA barcoding hidden Markov model Introduction A central aim of developmental biology is to better understand the embryonic differentiation and maturation pathways that lead to functioning adult cells ...