While both intrinsic (genetics) and extrinsic (brain environment) cues are coupled to glioma state identity, the functional programs governing glioma cell state and plasticity are unknown. Here we performed a multi-omic interrogation of a large library (n=392) of glioma patient tumors, in vivo ...
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Think of an adult learning situation that was very successful. How does neuroscience help explain why it was successful? A) How is the plasticity of the brain throughout life evident in recovery from brain damage? B) What are some factors...
What is the definition of personality? Define situational hypothesis Explain motivation in terms of being intrinsic and extrinsic. Discuss the importance of neural plasticity. Describe Person-Centered Therapy. Distinguish between convergent and divergent thinking. What is meant by the term 'normative group...
Ledonne A, Mercuri NB (2019) On the modulatory roles of neuregulins/erbb signaling on synaptic plasticity. IJMS 21:275. https://doi.org/10.3390/ijms21010275 Article CAS PubMed PubMed Central Google Scholar Leng F, Edison P (2021) Neuroinflammation and microglial activation in Alzheimer disease...
Cell state changes in the brain are closely related to neural plasticity. Similarly, various diseased conditions can induce pathological changes in cell states in different brain regions or tissue organs. Numerous studies have revealed selective vulnerability of specific cell types for specific diseases....
Moreover, GSC resists conventional radiotherapy and chemother- apy through their relative quiescence and plasticity [7]. Therefore, targeting GSC through identified cell surface markers has become a significant focus and this approach has showed promise to eliminate neoplastic progression in preclinical ...
The mechanism underlying selective myelination of axons versus dendrites or neuronal somata relies on the expression of somatodendritic membrane myelination inhibitors (i.e. JAM2). However, axons still present long unmyelinated segments proposed to contribute to axonal plasticity and higher order brain func...
lungprogenitors directed differentiation cell fate cellular plasticity heterogeneity single cell RNA sequencing DNA barcoding hidden Markov model Introduction A central aim of developmental biology is to better understand the embryonic differentiation and maturation pathways that lead to functioning adult cells ...
(SCLC) and become more responsive to chemotherapy37,38. One of the potential mechanisms of SCLC transformation might be the disruption in expression of cell-state-determining factors due toRB1inactivation15,39. The resulting lineage plasticity then converts the therapy-dependent cancer cells to ...