differing cleavage sites exhibited variable proteolytic sensitivities in blood, serum, and plasma. Therefore, future developments aiming at defining peptides as biomarkers must be preceeded by a careful analysis of their potential degradation (e.g. using isotope-labelled peptides), particularly in rele...
Anti-JC virus antibody levels in serum or plasma further define risk of natalizumab-associated progressive multifocal leukoencephalopathy. Ann Neurol. 2014;76(6):802-12.Plavina T, Subramanyam M, Bloomgren G, Richman S, Pace A, Lee S et al (2014) Anti-JC virus antibody levels in serum ...
RESEARCHARTICLE Anti–JCVirusAntibodyLevelsinSerum orPlasmaFurtherDefineRiskof Natalizumab-AssociatedProgressive MultifocalLeukoencephalopathy TatianaPlavina,PhD,MeenaSubramanyam,PhD,GaryBloomgren,MD, SandraRichman,MD,MPH,AmyPace,ScD,SophiaLee,PhD,BrianSchlain,MS, DeniseCampagnolo,MD,ShibeshihBelachew,PhD,MD,...
They demonstrated, again, that stenting does not provide a benefit compared with optimal medical therapy in terms of event-free survival, the primary end point of their analysis and the parent trial. The blood pressure response was similar between their groups, although the change in serum ...
The DIAN observational study examines ADAD mutation carriers and their noncarrier family members using multiple assessments including imaging, cognitive, CSF and plasma measures, among others. Because of the relatively precise estimated year of disease onset (EYO) in ADAD mutation carriers, cross-...
[160]. Interestingly, COX-2 is expressed in high concentrations in degenerative cells of the brain, thus inhibiting COX may reduce the risk of developing AD [168]. One study measured LPS-stimulated inhibition of plasma prostaglandin E2 (PGE2), an index of COX-2 activity ex vivo in ...
and confer disease pathology29. Saliva-derived EVs from PD patients have elevated levels of oligomeric α-synuclein compared to controls30. Serum neuronal exosomes of α-synuclein and clusterin could predict and differentiate PD from atypical parkinsonism31. Although CSF, saliva, and plasma-derived ...
Elevated plasma levels of low-density lipoprotein cholesterol (LDL-C) and reduced high-density lipoprotein cholesterol (HDL-C) are major cardiovascular disease (CVD) risk factors.1, 2, 3 Low HDL-C levels partly account for the residual risk of CVD despite statin monotherapy.4 Thus, improving ...
Downregulation of ceramide synthase-6 during epithelial-to-mesenchymal transition reduces plasma membrane fluidity and cancer cell motility. Oncogene. 2014;34:996–1005. Article PubMed CAS Google Scholar Silberman S, McGarvey TW, Comrie E, Persky B. The influence of ethanol on cell membrane ...
In highly overexpressing cells, a pool of GFP-epsin 2 was concentrated under the plasmamembrane despite the coalescence of clathrin coat components and of the majority of GFP-epsin 2 to the central region of the cell. It was shown previously that epsin 1 as well, when overexpressed by ...