PfHRPII has been implicated in (i) the production of hemozoin, the black pigment associated with disease, as well as (ii) interactions with the erythrocyte cytoskeleton. Here we show that a tripartite signal that is comprised of an endoplasmic reticulum-type signal sequence followed by a ...
About 75 000 new cases of melanoma were diagnosed in the United States in 2014 and the incidence rate is expected to rise in the next years.1,2Early stages can be treated with surgery but advanced tumors are usually highly metastatic and difficult to address, due to the poor response to...
or the host, or determining host responses that can report the presence of infection. At current, some developments are directed to the identification of a variety of biochemical by-products. For example, pyocyanin—the blue–green pigment secreted by manyP.aeruginosastrains...
At present, the biology that governs response to anti-PD-1 monotherapy compared with combined anti-CTLA-4 and anti-PD-1 immunotherapy is largely unknown. The only Food and Drug Administration-approved companion diagnostics are PD-L1 immunohistochemical assays; however, this is only applicable in th...