In total, we determined a panel of unique proteins and phosphoproteins as novel high-confidence candidates for disease biomarkers. Disease biomarkers will help diagnose whether a patient currently has PD. Our large-scale LC-MS analysis efforts combined with extensive bioinformatics analysis led to the...
Scale bar, 1 µm. e Summary showing sorting of cargos and SNARE proteins in early endosomes Full size image To shed more light on the functional differentiation between Stx6+/Stx13+ and Stx6+/Stx13− vesicles, we asked whether these two SNAREs are differentially sorted at the level ...
Scale bars: 500 nm; SEV inset: 25 nm. TEM was repeated at least twice on biological replicates from a mouse EGFR WT primary GBM culture. (F) Frequency and size (vesicle diameter in nm) distribution of vesicles from negative stain TEM in (E). The number of vesicles measured: SEV n =...
In total, we determined a panel of unique proteins and phosphoproteins as novel high-confidence candidates for disease biomarkers. Disease biomarkers will help diagnose whether a patient currently has PD. Our large-scale LC-MS analysis efforts combined with extensive bioinformatics analysis led to the...
5 mM CaCl2(pH 7.8) and 10 mM Tris (pH 7.4) respectively in a total volume of 10 μl for 3 hours and 6 hours. The enzyme activity was blocked by heating the sample at 95 °C for 3 minutes and analysed by Tricine SDS-PAGE. Digestion analysis was performed in triplicate...
in these cells. We used these cells for a small-scale drug-screening assay and detected several potential drugs that can reactivate HHV-6A. Drug-induced viral reactivation was further validated by detection of several viral IE transcripts. Various studies have advocated reactivation of HHV-6 in ...
Their use is now envisaged for a large variety of applications in many sectors, ranging from agriculture, for the enhancement of crop nutrition and protection [1], medicine, for cancer therapy [2], to environmental chemistry, for wastewater decontamination [3] and mechanical engineering, for ...