g-j, CD58 perturbation in co-culture does not affect B2M and HLA expression at the RNA and protein level but induces CD274. Distribution of fluorescent intensity by flow cytometry (corresponding to Fig. 5i-k) of MHC Class I and II, CD58, and PD-L1 in parental (control) and CD58 KO...
Acute perturbation strategies in interrogating RNA polymerase II elongation factor function in gene expression. Genes Dev. 35, 273–285 (2021). Article CAS PubMed PubMed Central Google Scholar Chen, F. X., Smith, E. R. & Shilatifard, A. Born to run: control of transcription elongation ...
Perturbation of cell wall synthesis suppresses autolysis in Staphylococcus aureus: evidence for coregulation of cell wall synthetic and hydrolytic enzymes. Bacterial peptidoglycan hydrolases are considered to have destructive potential, which in the presence of inhibitory concentrations of cell wall synthesis ...
Co-cultures persist through time and perturbation. Representative continuous co-cultures of E. coli W ΔcscR/cscB + S. elongatus (a) and W303Clump S. cerevisiae/cscB + S. elongatus (b) were cultured in photobioreactors with 1 mM IPTG. E. coli-containing consortia were grown in constant ...
CAFs promote cancer development and progression through diverse mechanisms including matrix remodeling, signaling interactions with cancer cells and perturbation of immune surveillance26,27,28. We observe a CAF cluster with high expression of known CAF marker genes FAP and TWIST1 (Extended Data Fig. 5a...
CAFs promote cancer development and progression through diverse mechanisms including matrix remodeling, signaling interactions with cancer cells and perturbation of immune surveillance26,27,28. We observe a CAF cluster with high expression of known CAF marker genes FAP and TWIST1 (Extended Data Fig. 5a...
1D). We then investigated whether genetic variation is associated with the expression of m6A regulatory factors in PRAD and found that the main factor leading to the perturbation of m6A regulatory factor expression is probably the change of CNV. CNV amplified m6A regulatory factors appear in PRAD ...