Fig. 1: Single-cell atlas of expression and chromatin accessibility in CRC development. a, Summary of the samples in this study. The bar chart shows the number of normal/unaffected colon tissues (gray), adenomas (purple) and CRCs (red) assayed for each patient. Locations of samples assayed...
We benchmarked our resistance variant map against COSMIC-curated drug response data45 and literature41,49 (Supplementary Note 7) revealing 35.29% concordance with screening data (Supplementary Table 16) and 252 edits at amino acid positions that had not been associated previously with altered drug re...
There are vast limitations given the low availability of commercial standards; however, making use of a combinatorial phytochemical approach including validation between literature- and web-based resources (Moco et al., 2006, Iijima et al., 2008, Tohge et al., 2014), and the use of biological...
The choice of the most suitable allocation technique is not a simple task, advantages and disadvantages are discussed in literature. Instead, if we start from the characteristics of the units available (input data), studying the structure (links in series and parallel), it is possible to ...
We further identified genes downregulated in adult AEC2s (MYCN, SOX11, and the Wnt target genes, NKD1, NKD2, and LGR5; Figure 1D). Based on prior literature (Frank et al., 2016, Hogan et al., 2014, Jacob et al., 2017), and significant differential expression between primary fetal ...
all links in the information chain were being properly represented and leveraged,” says Barbara Dobbs Mackenzie, president of NFAIS and editor in chief of Répertoire International de Littérature Musicale (RILM), a comprehensive database of music literature. “It was clear that wa...
We identified temporal pathway activation patterns during differentiation of iPSC-derived cardiomyocytes, and inferred in vitro toxicity profiles of drugs in primary human hepatocytes. In both cases results of molecular phenotyping were validated by either literature information or parallel experiments. ...
We benchmarked our resistance variant map against COSMIC-curated drug response data45 and literature41,49 (Supplementary Note 7) revealing 35.29% concordance with screening data (Supplementary Table 16) and 252 edits at amino acid positions that had not been associated previously with altered drug re...
The model is validated against two powertrain configurations: a conventional powertrain equipped with a continuously variable transmission (CVT) and a parallel hybrid powertrain. Powertrain parameters and performance data for validation for both cases are supplied from the literature. The model is shown ...
Box plots of individualqiw-values (on the y-axis) observed in parental and simulated 39-STR genotypes (on the x-axis) estimated from the Bayesian assignment analyses performed inParallel Structure, assumingK = 2 clusters and using the “Admixture” and “Independent allele frequencies” model...