In this optimization model, the spatial vessel organization is governed by cross-talk between vascular structures and the surrounding tissues, and involves integration of local metabolic and hemodynamic cues1,2,3. However, the molecular and cellular substrates that add organ specificity to the vascular...
The nervous system is the organ system responsible for controlling all voluntary and involuntary functions in the body. It is composed of structures such as the brain and the spinal cord. Answer and Explanation: Learn more about this topic: ...
How does the reproductive system work with other systems to maintain homeostasis? Provide at least one example of what occurs if homeostasis is not maintained. Discuss the concept of homeostasis, and point out how this is maintained in the body and the i...
The metastasis-invasion cascade describes the series of steps required for a cancer cell to successfully spread from its primary tumor and ultimately grow within a secondary organ. Despite metastasis being a dynamic, multistep process, most omics studies
The hype that these systems could recapitulate organ function5 is gradually being replaced by hope that such systems might enable more eloquent models for drug discovery reducing the reliance on animals which has ethical, monetary, time and translational advantages. Using a 'heart-on-a-chip' that...
These mRNA expression profiles were partially corroborated by the reporter modified bacterial artificial chromosome (BAC) transgenic (Tg) mouse lines. For example, as we described and confirmed previously44, a BAC clone covering theCdh6-5′ genomic region (Fig.3a) carries the specif...
concrete recommendations to help teachers reduce common behavior problems, •• define the behavioral model and its characteristics, •• describe the misunderstandings of the behavioral model, and •• specify the right to effective behavioral treatment and the right to an effective education....
The developmental program rolls out not only a temporal but also an elaborate spatial plan, specifying the location of each tissue organ and the spatial organization of all the cell types within each. This is a highly dynamic spatiotemporal process involving specific cell-cell interactions, cell ...
Mintzberg is credited with co-creating the Organigraph. He has written extensively on management and business Strategy. His contribution to Organizational Theory in the form of “The Organizational Configurations Framework” is a model that describes 6 valid organizational configurations orOrganizational Des...
- Evidence of similarity in key absorption, distribution, metabolism (see also below) and excretion (ADME) properties*- Level of target organ exposure (indicated by bioavailability, plasma/organ concentration–time profile; maximal or steady-state concentrations)Metabolism:- Similarity in metabolic ...