a, Base editing screens reveal clinically apparent hotspot mutations in oncogenes. Comparison of total COSMIC mutation counts for amino acid positions were compared with the z-score of gRNAs tiling across AKT1 and PIK3CA in HT-29 cells. b, Drug resistance variants to the PI3K inhibitor, pictili...
a, Base editing screens reveal clinically apparent hotspot mutations in oncogenes. Comparison of total COSMIC mutation counts for amino acid positions were compared with the z-score of gRNAs tiling across AKT1 and PIK3CA in HT-29 cells. b, Drug resistance variants to the PI3K inhibitor, pictili...
Genetic variation and expression of m6A regulators in prostate cancer (A) Mutation spectrum of m6A regulators (B) The location of the m6A regulators on the chromosome (C) The CNV landscape of the 29 m6A regulators (D) Gene expression level of the 29 m6A regulators. * P < 0.05; **...
In recent years, the advancement of sequencing techniques has enabled researchers to investigate and understand the involvement of microbes and metabolites in the development of colonic tumorigenesis. Previous studies have identified some site-specific bacteria [14,15,16] and distinct host genetic characte...
Associations of pathological diagnosis and genetic abnormalities in meningiomas with the embryological origins of the meninges Article Open access 26 March 2021 First insight into the somatic mutation burden of neurofibromatosis type 2-associated grade I and grade II meningiomas: a case report comprehen...
Mutation of the neurofibromatosis 2 (NF2) gene on chromosome 22q12 is a frequent and early event in meningioma tumorigenesis [9]. Atypical and malignant meningiomas have more complex genetic alterations with losses of the G1-S phase cell cycle checkpoint regulators, CDKN2A and CDKN2B, and p14...
The median age of the total cohort was 62 years, 34% had an elevated baseline lactate dehydrogenase, and 34% had tumors that were BRAF-mutation positive (Table 1). The progression-free survival (PFS) and overall survival of the anti-PD-1 monotherapy and the combined anti-CTLA-4 and anti...
The resulting fractions of tumors with predicted mutations in IDH1 (IDH1R132H, n = 6) and H3F3A (OLIG2+/FOXG1− for K27, n = 37, and OLIG2−/FOXG1+ for G34, n = 21) were consistent with the frequency of each mutation in the pediatric population as detected by targeted ...
but did not eliminate IRR donor activity, implying that the protein had a weaker affinity for BIRL. Further evidence for some protein interaction with the BIRLsequence is that in IRL, its mutation (a triplet of point mutations) all but eliminated minicircle formation. These results suggested that...
The initiation of flowering is an important developmental transition as it marks the beginning of the reproductive phase in plants. The MADS-box transcription factors (TFs) FLOWERING LOCUS C (FLC) and SHORT VEGETATIVE PHASE (SVP) form a complex to repres