Modulating the structure and properties of cell membranes: the molecular mechanism of action of dimethyl sulfoxide. J Phys Chem B. 2007;111:10453–60. Article CAS PubMed Google Scholar Notman R, Noro M, O’Malley B, Anwar J. Molecular basis for dimethylsulfoxide (DMSO) action on lipid ...
data from NAM, -omics or high content assays used to confirm similarity in mechanism of toxic action Variable – data from NAMs may be directly associated with mechanism of action; however difficult to definitively assign using “high content” / -omics data Obtain relevant data from biological ...
We report that two of these genes are homologous to each other and define a novel gene family that encodes over a dozen multipass transmembrane proteins. Our findings may have clinical implications for the mechanism of action of fluoxetine. 展开 ...
The mechanism of action of heparin on the coagulation system is well characterized at molecular level and acts by carbohydrate-protein interaction resulting in proteases inhibition mediated by serpins1. World consumption of heparin has been increasing significantly mainly due to more precise diagnosis of...
In summary we have mapped for the allosteric pocket of the P2X7R and provide a mechanism of action for antagonist inhibition of P2X7Rs. P2X7R selective antagonists have been suggested for targeting disease states where new therapies are needed, e.g. Alzheimer’s disease and pathologies where infl...
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT Inhibition of cholesteryl ester transfer protein (CETP) is considered a potential new mechanism for the treatm... R Krishna,A Garg,J Bo,... - 《British Journal of Clinical Pharmacology》 被引量: 174发表: 2010年 ...
of PIP2in treated cells [7]. The mechanism of action of U73122 is currently unknown [8], although an examination of its structure can provide some insight into the biologically active domains of the molecule. The inhibitory activity of U73122 can be reduced by alteration of the C17 side ...
“window” into the wound microenvironment. We therefore hypothesized that the peptide profile could reflect the action of different proteases present in wounds. However, the complexity of such peptide systems, and lack of efficient analytic tools, until recently has hampered their clinical exploitation...