Apararenone suppressed the decrease in urinary sodium and potassium ion ratio that occurs after loading with fludrocortisone. These studies support the mechanism of action of apararenone as an MRA, and further clinical development is warranted.doi:10.1002/cpdd.855Tadakatsu Nakamura...
data from NAM, -omics or high content assays used to confirm similarity in mechanism of toxic action Variable – data from NAMs may be directly associated with mechanism of action; however difficult to definitively assign using “high content” / -omics data Obtain relevant data from biological ...
In summary we have mapped for the allosteric pocket of the P2X7R and provide a mechanism of action for antagonist inhibition of P2X7Rs. P2X7R selective antagonists have been suggested for targeting disease states where new therapies are needed, e.g. Alzheimer’s disease and pathologies where infl...
These studies support the mechanism of action of apararenone as an MRA, and further clinical development is warranted. 展开 关键词: apararenone pharmacodynamics pharmacokinetics phase 1 safety DOI: 10.1002/cpdd.855 收藏 引用 批量引用 报错 分享 ...
A novel mechanism of PKA anchoring revealed by solution structures of anchoring complexes EMBO J., 20 (2001), pp. 1651-1662 View in ScopusGoogle Scholar 15 G.N. Sarma, F.S. Kinderman, C. Kim, S. von Daake, L. Chen, B.C. Wang, S.S. Taylor Structure of D-AKAP2:PKA RI complex...
“window” into the wound microenvironment. We therefore hypothesized that the peptide profile could reflect the action of different proteases present in wounds. However, the complexity of such peptide systems, and lack of efficient analytic tools, until recently has hampered their clinical exploitation...
of PIP2in treated cells [7]. The mechanism of action of U73122 is currently unknown [8], although an examination of its structure can provide some insight into the biologically active domains of the molecule. The inhibitory activity of U73122 can be reduced by alteration of the C17 side ...
A particular phenomenon of PK/PD analysis is hysteresis, which refers to the delay of the bioresponse time-course with respect to exposure time-course, as this provides valuable information on the direct or indirect nature of the drug mechanism of action. The application of these concepts to ...