Understand the meaning of fertility rate in biology, discover the formula for calculating the fertility rate, and know why the fertility rate is important. Related to this Question What is the difference between the replacement fertility rate (RFR) and the total fertility rate (TFR)?
Fig. 8: Model for transcription-factor driven lung metastasis in osteosarcoma. Schematic model illustrating the role of dynamic modulation of the epigenome during metastatic colonization in osteosarcoma. Full size image Our work also provides insights into the basic biology underlying osteosarcoma lung met...
The largest family contains theEPAgene family, some of which are known to mediate adhesion to different types of cells, among which are epithelial cells (EPA1,EPA6andEPA7primarily) and are considered a virulence factor inN. glabratus[19]. In a previous report based on short read genome sequ...
We then measured the interferon-γ (IFNγ) and tumour necrosis factor-α (TNFα) production in CD8+ T cells by flow cytometry (Fig. 3a, b and Extended Data Fig. 7b). We found responses in three of the five R248Q samples, with the response proportional to the size of the CD8+ T ...
In sum, a whole new field has emerged, devoted to the investigation of the molecular mechanisms, the cell biology, the physiological and pathological implications of contact sites. While it is now obvious that such appositions are central to the structure and function of any eukaryotic cell and...
To better understand the biology of response to anti-PD-1 monotherapy, we performed a multi-factor design analysis to first identify genes that were differentially expressed between responders and non-responders at baseline (pre-treatment [PRE]; n = 22 biopsies from 22 responders, n = 19 biopsi...
Antagonists of several growth factor signaling pathways play important roles in developmental patterning by limiting the range of the cognate inducer. Here... N Hacohen,S Kramer,D Sutherland,... - 《Cell》 被引量: 1652发表: 1998年 A CONSERVED SIGNALING PATHWAY: The Antagonists of several growth...
Enhanced expression of transforming growth factor-β1 in inflammatory cells, α-smooth muscle actin in stellate cells, and collagen accumulation in experim... Although toxocaral granulomatous hepatitis (TGH) characterized with a dominant-Th2 type immune response is a self-limiting disease, little is...
(1) AS is a more upstream factor involved in the regulation of cellular activities, whereas gene expression profiles are usually dominated by secondary, downstream responses; (2) AS profiles are largely polarized in single-cell data, i.e., for most AS events, each single cell bears just one...
After washing four times with ice-cold PBS, cells were incubated with Protein-A-10 nm gold conjugate (UMC Utrecht Department of Cell Biology) which recognizes the Fc portion of the mouse IgG2b primary antibody. Cell were again washed four times with ice-cold PBS and then stimulated with ...