The absorption efficiency of cholesterol is most likely determined by the net effect between influx and efflux of intraluminal cholesterol molecules across the brush border of the enterocyte. Combination therapy using a novel, specific, and potent cholesterol absorption (NPC1L1) inhibitor (ezetimibe) ...
To explore the effects of radiation therapy on the tumor and its immune microenvironment, we extended the in silico agent-based TIES model to incorporate the cytotoxic impact of radiation on both tumor/immune cells and the influx/efflux of immune infiltrates (Fig. 4A, see Methods). In this si...
cytosolic pool size, and exchange kinetics, and show that, with increasing external [K+] ([K+]ext), both influx and efflux increase dramatically, and that the ratio of efflux to influx exceeds 70% at [K+]ext ≥ 20 m. Increasing [K+]ext, furthermore, leads to a shortening of th...