Breast cancer (BC) is defined by distinct molecular subtypes with different cells of origin. The transcriptional networks that characterize the subtype-specific tumor-normal lineages are not established. In this work, we applied bulk, single-cell and single-nucleus multi-omic techniques as well as ...
Drug resistance is a principal limitation to the long-term efficacy of cancer therapies. Cancer genome sequencing can retrospectively delineate the genetic basis of drug resistance, but this requires large numbers of post-treatment samples to nominate ca
in vitro cell linesreconstituted basement membranenude miceThe incidence of many cancers shows a sharp increase with age. This is particularly true of prostate cancer, which arises in many older males. Little or no morbidity is observed as the tumor develops in situ in the prostate. However, ...
aMaintenance bacillus Calmette-Guerin immunotherapy for recurrent Ta, T1 and carcinoma in situ transitional cell carcinoma of the bladder: a randomized Southwest Oncology Group Study. 维护杆菌Calmette-Guerin免疫疗法为周期性Ta、T1和膀胱的癌在原处过渡细胞癌: 一项被随机化的西南肿瘤学小组研究。[translate]...
Cancer Res., 54 (1994), pp. 1305-1312 View in Scopus Kennedy et al., 1991 Kennedy M.A., Gonzales-Sermiento R., Kees U.R., Lampert F., Dear N., Boehm T., Rabbits T.H. Proc. Natl. Acad. Sci. USA, 88 (1991), pp. 8900-8904 CrossrefView in Scopus Kessel et al., 1991...
Interphase fluorescent in situ hybridization (FISH) Dual color FISH was carried out on FFPE sections as previously described [32] using a commercially available 1q25 (spectrum green) and 1p36 (spectrum orange) probe (Vysis® Abbott Laboratories, Abbott Park, IL, USA). FISH slides were examined...
However, both in lung and many other organs, combined small cell/non‐small cell tumors and secondary transitions from non‐small cell carcinomas upon cancer therapy to neuroendocrine and small cell tumors occur. We define features of "small cell‐ness" based on neuroendocrine markers, ...
OncLive spoke with one of the study authors, Philip McCarthy, MD, professor of Oncology and director of the Blood and Marrow Transplant Center at Roswell Park Cancer Institute, who explained the significance of these results. OncLive: How do the results of this study impact the treatment paradig...
Conclusion: Our results indicate that intracellular patterns of sialophorin expression define a new molecular classification of breast cancer and that sialophorin represents a novel therapeutic target. Despite recent improvements in mortality rate, breast cancer remains the second leading cause of cancer-...
Cancer Genet Cytogenet 2005;162:85–88. 10 Cook JR, Aguilera NI, Reshmi-Skarja S, et al. Lack of PAX5 rearrangements in lymphoplasmacytic lympho- mas: reassessing the reported association with t(9;14). Hum Pathol 2004;35:447–454. 11 Treon SP, Xu L, Yang G, et al. MYD88 L265...