Process design aided by machine learning. Define your connected facilities (departments, work cells, service stations, etc.) and the software will guide you in sizing your network (number of servers/employees, waiting time, queues, etc.). - GitHub - AI-T
Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct entities, cellular origins and genetic drivers than anticipated from histological assessment. DNA methylation profiling has emerged...
More attention has been paid to the genomic differences among theNakaseomycesspecies. The genome ofN. bracarensiswas first sequenced 10 years ago in a comparative genomics analysis of the sixNakaseomycesspecies that were known at that time [3]. In that analysis, the genomic basis for virulen...
The quantification of these immune cell populations can be used to predict patient response to the current anti-PD-1-based therapies, while identifying the group of patients in need of other therapeutic strategies. We also find that non-responders to monotherapy often express alternate immune ...
(B) Oncoprint depicts genetic features of breast cancer cell lines relative to the clustering. Specific cell lines used functionally are summarized in the box. (C) Live cell imaging was used to explore the impact of CCNE1 knockdown in the absence and presence of palbociclib in the MB157 cell...
Finally, we assessed changes in contact domains, defined as discrete regions of increased chromatin interactions above background, using the Arrowhead algorithm (Rao et al., 2014). Although the number and size of contact domains were not significantly altered between WT and Wizdel cells, the overl...
There are significant data to support that radiosensitivity has at least in part, a genetic basis, which we hypothesize acts in concert with the complex and highly dynamic tumor immune milieu to dictate response to therapy. However, radiosensitivity and immune signatures are almost exclusively derived...
To visualize potential single cell-fate trajectories in our model while preserving high-dimensional relationships, we first utilized the SPRING algorithm (Weinreb et al., 2018a) to prepare force-directed layouts of k-nearest neighbor graphs for the entire differentiation time series (Figure 3C). GFP...
Three further epigenetic subgroups were enriched for hallmark genetic events of adult GBM and/or established transcriptomic signatures. We also demonstrate that the two H3F3A mutations give rise to GBMs in separate anatomic compartments, with differential regulation of transcription factors OLIG1, OLIG...
(A) Heatmap of tumor (n = 85) and non-tumor (n = 66) samples based on the 16 EVP proteins revealed by random forest algorithm in figure 2D-E. (B) Classification error matrix using a random forest classifier of 75% training set and 25% test set.The analyses were based on the most...