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To study associations between genetic variants and morphological traits, we assembled a cohort of iPSC lines from 297 unique donors for which we generated image-based profiling and whole-genome sequencing data (Fig.1). We obtained pre-derived cell lines from the CIRM iPSC repository5. Age, sex,...
a, Summary of benign breast duct cell types and BC subtypes. The image was created with BioRender.com.b, Sample grid processing method utilized in the study to perform various assays on each tumor sample systematically.c, Summary of data types available for single-cell, single-nucleus and ST ...
If I make the Fresh project first and then attempt to Prisma Init inside of the project everything will work other than the generation, thats where we get this error. janpioaddedbug/1-unconfirmedBug should have enough information for reproduction, but confirmation has not happened yet.bug/2-...
We present a comprehensive investigation into the specification and generation of bona fide NC using a straightforward pluripotent stem cell (PSC)-based system benchmarked with human fetal notochord. By integrating in vitro and in vivo transcriptomic data at single-cell resolution, we establish an ...
METHODS. We analyzed 20 tumor samples by histology, RNA Next-Generation Sequencing, DNA-methylation profiling, copy number analyses, and single nucleus RNA sequencing (snRNA-seq). Clinical data, including age, sex, and disease progression, were collected. MRI series were included when available. ...
The median age of the total cohort was 62 years, 34% had an elevated baseline lactate dehydrogenase, and 34% had tumors that were BRAF-mutation positive (Table 1). The progression-free survival (PFS) and overall survival of the anti-PD-1 monotherapy and the combined anti-CTLA-4 and anti...
(1965–2014), and a tendency towards significance on Table 4 Clinical characteristics and distribution of WHO grade in three different ependymoma groups defined by TNC expression and chromosome 1q25 status Gender Median age WHO grade (m:f ratio) years (range) (II/III) TNC pos/1q25 gain (...
In the current study, we attempt to capture a wide range of biological pathways by collecting reporter genes using an integrative approach. We demonstrate that a molecular phenotypic screening approach can be used to monitor pathway activation patterns in different cellular systems using the latest ...
The biochemical analyses were performed on mononuclear cells isolated from peripheral blood, obtained from a healthy population with an age between 5 and 106 years. In particular, we have evaluated the oxidative phosphorylation function and efficiency, the ATP/AMP ratio, the lactate dehydrogenase ...