Sabari (UTSW) for feedback and help; and C. Buecker and H. Thomas (MPL), C. Plaschka (IMP) and A. Andersen (Life Science Editors) for comments on the manuscript; the staff at the IMP/IMBA in-house FACS facility, in particular G. Schmauss, and staff at the Molecular Biology ...
15,16,17. In particular, the reported expression of members of the galectin family, tissue lectins with β-galactoside binding capacity18,19, has stimulated the research of their functional implications in nervous system physiology. So
Host protein synthesis is inhibited by SARS-CoV-2 non-structural protein 1 (Nsp1)42. Importantly, viral RNAs escape this inhibition utilizing Stem-Loop 1 (SL1) in the 5′-UTR43. This feature is present in the sgRNA (Figs.2a,3f) and bicistronic frameshift reporters (Fig.2f), and thus t...
This effect is most apparent in strains of B. subtilis (Fig. 3b, Additional file 1: Figure S4A) where the viability of heterotrophic species decreases by orders of magnitude when co-cultured in the light with high concentrations of S. elongatus. The inhibition of B. subtilis growth while in...
The activity of the Dpp morphogen adapts to tissue size in the growingDrosophilawing imaginal disc, and Pentagone, an important secreted feedback regulator... F Hamaratoglu,AMD Lachapelle,G Pyrowolakis,... - 《Plos Biology》 被引量: 118发表: 2011年 Kwon, C., Hays, R., Fetting, J. &...
Inhibition of PI3K/Akt reduced mTOR activity, which effectively enhanced the anticancer effort of an mTOR inhibitor. ATP-binding cassette subfamily C member 4 (Abcc4) was found to be responsible for p53 haploinsufficiency- and Tsc1 loss-driven HCC tumorigenesis. Moreover, in clinical HCC samples,...
considering tumor biology and microbial interactions in studies of the CRC microbiome. Methods Human subject enrollment Adults (older than 18 years old) who were determined to be candidates for colorectal cancer surgery were voluntarily enrolled at Mayo Clinic in Rochester, Minnesota. Exclusion criteria...
in agonist-stimulated cells, consistent with inhibition of PLC, this may have been an indirect effect of a shortage in substrate availability [11]. In U73122-treated mouse fibroblasts and rat neutrophils, inhibition of Ca2+influx across the plasma membrane contributed to the suppression of Ca2+...
Clinical outcome for patients suffering from HPV-negative head and neck squamous cell carcinoma (HNSCC) remains poor. This is mostly due to highly invasive tumors that cause loco-regional relapses after initial therapeutic intervention and metastatic out
As miR-101 targets EZH2, its repression establishes a feed-forward loop, which results in the stable upregulation of EZH2 and the stable downregulation of miR-101.11,12 To address the potential contribution of these pathways to the biology of FGF-2-expressing bladder carcinomas, we searched ...