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(A) Diagram of TE culture method for EVPs isolation from paired TT and AT and matched DT (for LuCa). (B) Top 30 proteins highly represented in PaCa TT compared to AT (top), and LuCa TT compared to AT and DT (bottom). The heatmap is based on proteins found >50% of TT at leve...
37, an Hsp104 variant lacking the N domain (Hsp104ΔN) is functional and cooperates with Hsp70/40 in protein disaggregationin vitro(Fig.4a). Because the N domain adopts a stably folded conformation that does not make strong contacts with the D1 domain in the Hsp104 hexamer...