EffectorVirulenceAvirulenceCompatibility between plant parasites and their hosts is genetically determined {Citation}both interacting organisms. For example, plants may carry resistance (R) genes or deploy chemical defences. Aphid saliva contains many proteins that are secreted into host tissues. Subsets of...
Clinical characteristics of refractory COVID-19 pneumonia in Wuhan, China. Clin. Infect. Dis. https://doi.org/10.1093/cid/ciaa270 (2020). Khan, S. et al. Emergence of a novel coronavirus, severe acute respiratory syndrome coronavirus 2: biology and therapeutic options. J. Clin. Microbiol. ...
2020, Nature Reviews Microbiology PAM identification by CRISPR-Cas effector complexes: diversified mechanisms and structures 2019, RNA Biology Molecular mechanisms of CRISPR–Cas spacer acquisition 2019, Nature Reviews Microbiology View all citing articles on Scopus ...
Among the three clusters of tumor cells, those in C2 were generally more differentiated than the others (Figs.2C,S4A). Note that the cell clusters defined by gene expression profiles did not show such significant differences in their differentiation stages (Fig.S4B). Furthermore, compared to th...
(n = 57). These data identified activated T cell signatures and T cell populations in responders to both treatments. Further mass cytometry analysis identified an EOMES+CD69+CD45RO+effector memory T cell phenotype that was significantly more abundant in responders to combined immunotherapy compared ...
Promoters control the expression of genes in response to one or more transcription factors (TFs). The architecture of a promoter is the arrangement and typ... RS Cox,MG Surette,MB Elowitz - 《Molecular Systems Biology》 被引量: 513发表: 2007年 Antisense therapy for cancer--the time of trut...
Lee, E. G. et al. Failure to regulate TNF-induced NF-κB and cell death responses in A20-deficient mice.Science289, 2350–2354 (2000). ArticleCASPubMedPubMed CentralGoogle Scholar Hasegawa, K. et al. PEST domain-enriched tyrosine phosphatase (PEP) regulation of effector/memory T cells.Sci...
KP tumors demonstrated higher levels of somatic mutations, inflammatory markers, immune checkpoint effector molecules and improved relapse-free survival. Differences in drug sensitivity patterns were also observed; notably, KL cells showed increased vulnerability to HSP90-inhibitor therapy. This work ...
chemokines as well as activate T effector cells. Over the past decade, studies using single-cell RNA-sequencing (scRNA-seq) have identified an even wider spectrum of subsets in both health8and disease9,10,11,12,13,14,15,16,17,18,19,20. The diverse activation states of alveolar monocytes...
4c). To build a predictive model for KRAS, we were able to include measured binding affinities to the downstream Raf effector protein for a limited set of hotspot mutations25 (Supplementary Methods), in addition to inferences in conservation and immunogenicity (Extended Data Fig. 4d). Fig. 2:...