1. Definition of Dominant: Dominant refers to a genetic trait that is expressed or appears in the phenotype of an organism when at least one dominant allele is present. 2. Example of Dominant Trait: In the context of Mendelian genetics, consider a trait for plant height. The tall plant...
Analysis of Dominant Enhancers and Suppressors of Activated Notch in Drosophila The Notch receptor controls cell fate decisions throughout Drosophila development. Truncated, ligand-independent forms of this protein delay or block diffe... EM Verheyen,KJ Purcell,ME Fortini,... - 《Genetics》 被引量...
Michael Yudell, a professor of public health at Drexel University in Philadelphia, said that modern genetics research is operating in a paradox: on the one hand, race is understood to be a useful tool to illuminate human genetic diversity, but on the othe ...
Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer’s disease Erik C. B. Johnson, Shijia Bian, Rafi U. Haque, E. Kathleen Carter, Caroline M. Watson, Brian A. Gordon, Lingyan Ping, Duc M. Duong, Michael P. Epstein, Eric McDade, Nicolas...
It was established that the Ppd-s line contains a dominant Ppd-D1a allele located on chromosome 2D. This allele is characterized by a large deletion in the gene promoter region. For two other lines (Ppd-m and Ppd-w), introgression of the Ppd-B1 gene on chromosome 2B w...
Because germline TP53 mutations are the primary cause of Li–Fraumeni syndrome (LFS), which is a highly cancer-prone autosomal dominant disorder28, we theorized that mutant p53 fitness relates to the time to first tumour formation in patients with LFS. We plotted Kaplan–Meier curves showing the...
The molecules share the same key structural fragment that is responsible for the dominant mode of action. There are no structural fragments that would be expected to affect toxicity significantly. All relevant physico-chemical properties are similar. Toxicodynamics Toxicology Effect responsible for ...
In autosomal dominant polycystic kidney disease (ADPKD), cysts accumulate and progressively impair renal function. Mutations in PKD1 and PKD2 genes are causally linked to ADPKD, but how these mutations drive cell behaviors that underlie ADPKD pathogenesis is unknown. Human ADPKD cysts frequently express...
Although cDCs, pDCs, macrophages, and both monocyte subsets populated all analyzed tissues, we found that macrophages and monocytes represented the dominant cell types in peripheral tissues, while cDCs were highly abundant in lymphoid tissues. Further, cDC2s accounted for the majority of cDCs in the...
Cossette P, Liu L, Brisebois K, Dong H, Lortie A, Vanasse M, Saint-Hilaire JM, Carmant L, Verner A, Lu WY, et al: Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. Nat Genet. 2002, 31: 184-189. CAS PubMed Google Scholar Baulac S, Huberfeld G...