Next-generation sequencing was performed at diagnosis in 22 patients. Median age was 62 years (range, 19-86). Twenty-four patients (77%) had normal karyotype, and all had multilineage dysplasia. Most patients could be classified as MDS with excess blasts (19/31, 61%). NPM1 mutations were...
Multiplex cerebrospinal fluid proteomics identifies biomarkers for diagnosis and prediction of Alzheimer’s disease Article 10 July 2024 Main AD is a devastating neurodegenerative disease with increasing prevalence in aging societies1. AD is currently defined at a research level by the presence of high...
Identification of microRNAs in the cerebrospinal fluid as biomarker for the diagnosis of glioma. Malignant gliomas are the most common and lethal primary intracranial tumors. To date, no reliable biomarkers for the detection and risk stratification of ... Alexander,Baraniskin,Jan,... - Neuro-oncolo...
(p = 0.03, OR CI = 0.086-0.93) to electroacupuncture treatment (18% and 44% for subgroups 1 and 2, respectively).DISCUSSION\nOur study proposed a novel clustering approach to define distinct MWoA subgroups, which could be useful for refining the diagnosis of participants with MWoA and guiding...
(Fig.1dand Supplementary Table1). Of these, the patient aged 30 (HT163B1) had a family history, including two other family members with BC diagnosed in their thirties. In all, 21 of the 37 patients had a known first-degree family member with a cancer diagnosis, though only 7 of these...
22 Third, this analysis was intentionally limited to operative procedures performed within 2 days of admission for an EGS-related diagnosis. As such, it does not account for the burden of trauma-related procedures or semi-elective procedures that take place many days after admission. Fina...
Duchenne muscular dystrophy is a genetic disease linked to the X chromosome that affects mostly boys. Learn what Duchenne muscular dystrophy is, why it occurs, the affected locations, clinical signs, diagnosis, and treatments for patients with the disease. Related...
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diagnosis21,22. Moreover, since phosphorylation events directly reflect cellular physiological status during neurodegeneration, urinary EVs represent a highly promising source of phosphoproteins as non-invasive disease markers23,24. Previous studies from our group have identified numerous EV proteins and ...
For PURE01, the paraffin block at diagnosis was used as the primary tissue for evaluation. Paraffin blocks were stored at room temperature. A GU pathologist evaluated every section and identified the high grade and invasive parts of the tumor, which were then macro-dissected for dual RNA and ...